Protein Info for LRK55_RS03920 in Rhodanobacter denitrificans MT42

Annotation: adenosylmethionine--8-amino-7-oxononanoate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 TIGR00508: adenosylmethionine-8-amino-7-oxononanoate transaminase" amino acids 19 to 444 (426 residues), 570.1 bits, see alignment E=1.1e-175 PF00202: Aminotran_3" amino acids 31 to 443 (413 residues), 360.7 bits, see alignment E=4.2e-112

Best Hits

Swiss-Prot: 43% identical to BIOA_ANOFW: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA) from Anoxybacillus flavithermus (strain DSM 21510 / WK1)

KEGG orthology group: K00833, adenosylmethionine-8-amino-7-oxononanoate aminotransferase [EC: 2.6.1.62] (inferred from 66% identity to gpb:HDN1F_36550)

Predicted SEED Role

"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.62

Use Curated BLAST to search for 2.6.1.62

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (454 amino acids)

>LRK55_RS03920 adenosylmethionine--8-amino-7-oxononanoate transaminase (Rhodanobacter denitrificans MT42)
MNNSASGNAALAARDLRHVWHPCTQMHDHESVPMVPIVRGEGAWLIDADGRRYLDGISSW
WTNLFGHANPRLAAALAEQARTLEHVIFAGFTHEPAIELAEELVRITPPGLDRVFYADNG
SAAIEVALKMSFHYWLNQGHGEKTRFIALTGSYHGETLGALSVSDVALYRKTYAPLLLTP
FLAPSPDAYEGEPGESPEQTAKRRLGELRTLLERHAHETCAVIVEPLVQCAGGMRMYHPG
YLSGLRALCDEFAVHFIADEIAVGFGRTGTLFACEQAAVTPDFMCLSKGLTGGTLPLSAV
LTRDVVYQAFYAEYNAGKAFLHSHSYTGNPLACRVALETLAIFRDEPVLERNRQLAVHLA
RRLQPLRAHPHVADVRQTGLIAAIELVADKASRRPYPAAERRGLRVYLHGLQHGALLRPL
GNVVYFMPPYVVSEAEIDQLVDTAIAGIERAVAD