Protein Info for LRK55_RS01380 in Rhodanobacter denitrificans MT42

Annotation: histidinol-phosphate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01141: histidinol-phosphate transaminase
  • amino acids 8 to 350 (343 residues), 353.5 bits, E=5.3e-110
• PF00155: Aminotran_1_2
  • amino acids 45 to 347 (303 residues), 186.6 bits, E=8.1e-59
• PF00266: Aminotran_5
  • amino acids 61 to 183 (123 residues), 26 bits, E=4.5e-10

Best Hits

Swiss-Prot: 57% identical to HIS8_XANC5: Histidinol-phosphate aminotransferase (hisC) from Xanthomonas campestris pv. vesicatoria (strain 85-10)

KEGG orthology group: K00817, histidinol-phosphate aminotransferase [EC: 2.6.1.9] (inferred from 57% identity to xcv:XCV1876)

Predicted SEED Role

"Histidinol-phosphate aminotransferase (EC 2.6.1.9)" in subsystem Histidine Biosynthesis (EC 2.6.1.9)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• L-histidine biosynthesis (10/10 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• L-phenylalanine biosynthesis I (3/3 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• L-tyrosine degradation I (4/5 steps found)
• 3-(4-hydroxyphenyl)pyruvate biosynthesis (1/1 steps found)
• L-tyrosine degradation II (1/2 steps found)
• atromentin biosynthesis (1/2 steps found)
• L-phenylalanine degradation III (2/4 steps found)
• L-tyrosine degradation III (2/4 steps found)
• L-phenylalanine degradation II (anaerobic) (1/3 steps found)
• L-tyrosine degradation IV (to 4-methylphenol) (1/3 steps found)
• superpathway of plastoquinol biosynthesis (2/5 steps found)
• superpathway of chorismate metabolism (40/59 steps found)
• 4-hydroxybenzoate biosynthesis I (eukaryotes) (1/5 steps found)
• L-phenylalanine degradation VI (reductive Stickland reaction) (1/5 steps found)
• L-tyrosine degradation V (reductive Stickland reaction) (1/5 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (2/9 steps found)
• rosmarinic acid biosynthesis I (1/10 steps found)
• (S)-reticuline biosynthesis I (1/11 steps found)
• superpathway of rosmarinic acid biosynthesis (1/14 steps found)
• anaerobic aromatic compound degradation (Thauera aromatica) (1/27 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of phenylpropanoids
• Histidine metabolism
• Novobiocin biosynthesis
• Phenylalanine metabolism
• Phenylalanine, tyrosine and tryptophan biosynthesis
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.9

Protein Sequence (353 amino acids)

>LRK55_RS01380 histidinol-phosphate transaminase (Rhodanobacter denitrificans MT42)
MSVLDLARPEIRAMQPYSSARMEASGGEVLLNANESAWAPVGDDGLGCNRYPEPQPAALV
EALATLYGVRREQLLVGRGSDEAIDLLVRAFCRAGRDAVLIQPPTFGMYAVCARVQDAGI
VEVPLAADATLDVDAVLAALTPAVKLVFVCTPNNPTGQPVPRTELERLVQALAGRALLVV
DEAYVEFADEGSVADLIDRYDNLAVLRTLSKAWALAGVRIGSLLASAGVIALLRRIMAPY
PLPLPSVDAALLALSGWGQANAREHLAVVRAERTRMCEALRWLRNVREVLPSQANFLAVR
FDDAAGAYQRLLAAGIVVRDVRRYLNLGDALRITIGTPAENERVLAVLQETSP