Protein Info for LRK54_RS17585 in Rhodanobacter denitrificans FW104-10B01

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1059 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 338 to 357 (20 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 446 to 467 (22 residues), see Phobius details amino acids 484 to 505 (22 residues), see Phobius details amino acids 535 to 556 (22 residues), see Phobius details amino acids 873 to 891 (19 residues), see Phobius details amino acids 898 to 918 (21 residues), see Phobius details amino acids 924 to 948 (25 residues), see Phobius details amino acids 981 to 1000 (20 residues), see Phobius details amino acids 1010 to 1035 (26 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1044 (1044 residues), 1279.5 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1036 (1031 residues), 793.4 bits, see alignment E=1.6e-242

Best Hits

Swiss-Prot: 60% identical to CUSA_ECOL6: Cation efflux system protein CusA (cusA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 63% identity to aex:Astex_3842)

MetaCyc: 60% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1059 amino acids)

>LRK54_RS17585 CusA/CzcA family heavy metal efflux RND transporter (Rhodanobacter denitrificans FW104-10B01)
MIAALIRVSIRYRVFVLLAALALAAVGVFSAWHTSIDALPDLSDTQVIIRTSYPGQSPQV
VEDQVTYPLATTMLSVPGATTVRAYSFFGDSYVDVLFSDSTDLYWARSRVLEYLSQARDR
LPAGVNPALGPDATGLGWIYEYALVDRTGRHDIGQLTALQNWNLRFQLKTVPGVAEVATL
GGMDRAWQIVPDPQALAARGLTVAQLVDAVRAANGANGGSVIEQGEAELMVRSEGYLKTR
ADFENVPIVANANGVPVRLRDVATVRRGPTFRRGLAELDGQGEVVGGIIVMRSGQNAKAT
IAAVKARLAQLQRSLPPGVEIVPTYDRSQLIDATVENVWRKLLEEFLVVTLVCALFLGHL
RSALVAVITLPLGVLTAFIVMNLQGVTANLMSLGGIAIAIGAMVDAAIVMIENTHKHLEH
WRDAHDGQEPQGAARWALIAEATVEVGPALFVSLLIIALSFVPVFALQGQEGKLFKPLAF
TKTYAMAAAAGLAVTLVPVLMGYLVRGHLRAEHANPINRGLIALYRPILDVVLRFPKATL
GLAALVLLTALVPLSQLGSEFMPAMDEGTLLYMPTALPGLSAGKAAQLLQLTDRMLKTVP
EVAHVFGKAGRADTATDPAPLEMFETTITFKPKSEWRPGMTMDKIKAALNQAVHVPGLTN
LFVPPIRNRIDMLSTGIKSPIGIKVLGTDLTTLQTVADRIEAVAKTVPGVSSAVAERPTS
GRYVDVHIRRDEAARYGLTQEAVQQLIATVVGGDPVGQSIEGRERFPIVVRYPRVDRDSV
QALRQLPIVAANGAQLTLSQVADITVAAGPSMLKSEDGQLATYVYIDTASSNLGGVVARL
QRAVARQVTLPPGVTLDWSGQFQYLASAAQRLKLVVPVALLIIFGLIYAVFRRTSEAALI
MANVPLALVGGLWLIWLLGHSVSVATVIGFIALAGVAAEFGVVMLLYLRHAWDRQLALDP
QAGVDALDEAIRQGAAQRVRPLAMTVAVIIAGLLPILLGHGAGSEVMQRIAAPMIGGMVT
ATLLTMLVLPAAFRLLMRYRLRKAAQSIPTFHPPQEIQP