Protein Info for LRK54_RS15670 in Rhodanobacter denitrificans FW104-10B01

Annotation: cbb3-type cytochrome c oxidase subunit I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 495 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 61 to 84 (24 residues), see Phobius details amino acids 96 to 120 (25 residues), see Phobius details amino acids 139 to 160 (22 residues), see Phobius details amino acids 199 to 223 (25 residues), see Phobius details amino acids 239 to 262 (24 residues), see Phobius details amino acids 275 to 295 (21 residues), see Phobius details amino acids 309 to 329 (21 residues), see Phobius details amino acids 342 to 362 (21 residues), see Phobius details amino acids 382 to 401 (20 residues), see Phobius details amino acids 419 to 438 (20 residues), see Phobius details amino acids 458 to 478 (21 residues), see Phobius details PF00115: COX1" amino acids 23 to 464 (442 residues), 147.5 bits, see alignment E=2.9e-47

Best Hits

KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 52% identity to neu:NE0683)

MetaCyc: 52% identical to nitric oxide reductase (sNAOR) A subunit (Nitrosomonas europaea)
NITRIC-OXIDE-REDUCTASE-RXN [EC: 1.7.2.5]

Predicted SEED Role

"Cytochrome c oxidase (B(O/a)3-type) chain I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.7.2.5, 1.9.3.1

Use Curated BLAST to search for 1.7.2.5 or 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (495 amino acids)

>LRK54_RS15670 cbb3-type cytochrome c oxidase subunit I (Rhodanobacter denitrificans FW104-10B01)
MSSLELYPQDEKLSRREHLAFNLYMITALLLFVLMMLLGLTMRMTQAEWTPVQAAMFYKI
MTMHGAGMVGTMSLASTAVMWFFLRKYVSLHAWAFLSNYVLFMLGALCIIGAVFVGNFAS
AWTFLYPLPVHSMGLWSNGAAAVFMVGYLLIGVGMLIFYLDAAAAIIRRYGNLARGLGLQ
WLFGGTIDPTHPKAVVAGTMVIIANSLGILAGAVVLVMCLINAYDPDVALNALVVKNLIY
WFGHMVINATIYMGVIAVYELLPRYTGKPYGISRPFLWSWAASTVFVIIVFPHHLLMDYA
EPRWMLVMGQIISYAAGFPVFLVTAYGVLTNIHRSGLRWQMPSMLAVLALFGWAAGIVPA
IIDGTISVNRVMHNTQWVPGHFHFYLLLGVLPMILTLLYHVVGSRRRAPVDGGVDRAGLF
LYAIGGISFCMVFLYAGHMSVARRFAAHLPEWLPYDRAGSVAAMVLILGMLLFATRLIGG
LLKAPVDADPAHPAG