Protein Info for LRK54_RS14270 in Rhodanobacter denitrificans FW104-10B01

Annotation: succinyl-diaminopimelate desuccinylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01246: succinyl-diaminopimelate desuccinylase
  • amino acids 5 to 375 (371 residues), 507.8 bits, E=8.2e-157
• PF01546: Peptidase_M20
  • amino acids 63 to 373 (311 residues), 141.9 bits, E=2.6e-45
• PF07687: M20_dimer
  • amino acids 176 to 281 (106 residues), 87.6 bits, E=5.4e-29

Best Hits

Swiss-Prot: 65% identical to DAPE_XANAC: Succinyl-diaminopimelate desuccinylase (dapE) from Xanthomonas axonopodis pv. citri (strain 306)

KEGG orthology group: K01439, succinyl-diaminopimelate desuccinylase [EC: 3.5.1.18] (inferred from 65% identity to xac:XAC1432)

MetaCyc: 50% identical to N-succinyl-L,L-diaminopimelate desuccinylase subunit (Haemophilus influenzae Rd KW20)
Succinyl-diaminopimelate desuccinylase. [EC: 3.5.1.18]

Predicted SEED Role

"N-succinyl-L,L-diaminopimelate desuccinylase (EC 3.5.1.18)" in subsystem Arginine Biosynthesis extended or Lysine Biosynthesis DAP Pathway (EC 3.5.1.18)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.18

Protein Sequence (382 amino acids)

>LRK54_RS14270 succinyl-diaminopimelate desuccinylase (Rhodanobacter denitrificans FW104-10B01)
MSDVLELARDLIRRRSVTPEDAGCLPLVGGRLARAGFAIEYLRHGEVDNLWATHGASSPT
LIFLGHTDVVPSGPEAAWQSPPFEPTVRDGRLYGRGTADMKGSVAAMVVALEQFAAAHPD
HRGRVGLLLTSDEEGPTNLDGVRKVAERFRVTGERIDWCVVGEPSAKETLGDLIRVGRRG
SLSGTLVVRGVQGHVAYPEKASNPIHAFAPALAELAATRWDEGNADFPPTSFQVSNLNAG
TGANNVIPGELTALINFRYGTASRADDLRARTEAILQRHGVDFALDWNLSGEPFLTPPGG
VLREVVVAVCRELCGIDPEQSTGGGTSDGRFIAPLGAEVVELGPVNASIHKVDECVALDE
LELLPRLYRAVCERLLTGTRSG