Protein Info for LRK54_RS13280 in Rhodanobacter denitrificans FW104-10B01

Annotation: UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00236: UDP-N-acetylglucosamine 2-epimerase
  • amino acids 40 to 359 (320 residues), 285.4 bits, E=3.6e-89
• PF02350: Epimerase_2
  • amino acids 61 to 394 (334 residues), 325.8 bits, E=2.9e-101

Best Hits

KEGG orthology group: K01791, UDP-N-acetylglucosamine 2-epimerase [EC: 5.1.3.14] (inferred from 60% identity to swi:Swit_4666)

Predicted SEED Role

"UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14)" in subsystem CMP-N-acetylneuraminate Biosynthesis or Sialic Acid Metabolism (EC 5.1.3.14)

MetaCyc Pathways

• UDP-N-acetyl-α-D-mannosamine biosynthesis (1/1 steps found)
• CMP-N-acetylneuraminate biosynthesis II (bacteria) (1/3 steps found)
• CMP-N-acetylneuraminate biosynthesis I (eukaryotes) (1/5 steps found)
• superpathway of CMP-sialic acids biosynthesis (2/15 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.14

Protein Sequence (424 amino acids)

>LRK54_RS13280 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) (Rhodanobacter denitrificans FW104-10B01)
MQIPASKPVYSRKTTPACGNVLLHSSHHGTGGCPVMQRLRIDLIAAARPNFMKVAPLFHV
LHEQPWCRLRLVHTGQHYDQNMSEAFFRDLKLPPPDLHLGVGSGSHAKQTADVMLAYEEA
CAADRPDLVVVVGDVNSTMACALVGAKLHIPIAHLEAGLRSGDRRMPEEINRLVTDTLAD
ILWTPSPDADEHLAAEGVPPEKITRVGNIMIDSYELMRERIDASGERRRLGLENHAYAVV
TLHRPSNVDTPTPLTALVDQLIRMAARLPLVFPVHPRTRKNLEAFGLCSKLADAPNLQVI
EPLGYVDFMNLVCGAHLAITDSGGIQEETTYLGIPCLTLRTTTERPITITEGTNRLVTAA
GLVPAVDEILAGRWPQGRKPRLWDGHTAARVAADIRRRLLRAPPHVAEATAVPATAHQRT
RGNA