Protein Info for LRK54_RS12315 in Rhodanobacter denitrificans FW104-10B01

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF13623: SurA_N_2" amino acids 6 to 113 (108 residues), 43.2 bits, see alignment E=1.1e-14 PF13624: SurA_N_3" amino acids 31 to 149 (119 residues), 60.2 bits, see alignment E=6.8e-20 PF09312: SurA_N" amino acids 33 to 150 (118 residues), 130.2 bits, see alignment E=1.4e-41 PF13616: Rotamase_3" amino acids 175 to 278 (104 residues), 62.7 bits, see alignment E=1.4e-20 amino acids 283 to 383 (101 residues), 70.9 bits, see alignment E=4.2e-23 PF00639: Rotamase" amino acids 183 to 276 (94 residues), 68 bits, see alignment E=3.7e-22 amino acids 294 to 383 (90 residues), 71.8 bits, see alignment E=2.4e-23 PF13145: Rotamase_2" amino acids 195 to 281 (87 residues), 37.5 bits, see alignment E=1.2e-12 amino acids 306 to 384 (79 residues), 30.8 bits, see alignment E=1.4e-10

Best Hits

Swiss-Prot: 48% identical to SURA_XANC5: Chaperone SurA (surA) from Xanthomonas campestris pv. vesicatoria (strain 85-10)

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 48% identity to xcv:XCV0902)

MetaCyc: 33% identical to chaperone SurA (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>LRK54_RS12315 peptidylprolyl isomerase (Rhodanobacter denitrificans FW104-10B01)
MKQSLAFLLFALAILLPAHAQLLTPAAPANQPLDRIVAVVNDDVILQSELNDAVLSVQQQ
YAGHTEQLPPMNVLQQQVLNRLVLMRLQIQKAQDQGIHVSDADVDQAIQGVAQQNKLSPE
QLRAEVERSGASFASFREQLADQITVQRLHQNVVRDSVSVTDSEIDNLLSSPTYKAGEVH
LAHIQISIPGGADAAAIQASQAKAEQTLAAIKGGMDFNAAAIRYSDAPDALDGGDLGWRR
LDEIPPAFADTITSMKPGEVSAALRGPTGFHILKLVDQRQSSRKMVTELHARQILIKPSE
LLTPAQAEQKAQDLYHRIVDKHEDFATLAKENSKDDTTANIGGDMGWFPPQAWGQAIAAQ
LGQLKDNQVSAPFQSAAGWHILQRLGERQSDQTVQIERDQARQAIGTRKSEQAYDDYLRD
LRSNAYVDILVPELRAADDRAAASAP