Protein Info for LRK54_RS10265 in Rhodanobacter denitrificans FW104-10B01

Annotation: multicopper oxidase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 659 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 62 to 82 (21 residues), see Phobius details amino acids 89 to 115 (27 residues), see Phobius details amino acids 128 to 150 (23 residues), see Phobius details amino acids 196 to 215 (20 residues), see Phobius details PF07732: Cu-oxidase_3" amino acids 263 to 372 (110 residues), 47.7 bits, see alignment E=4.1e-16 PF07731: Cu-oxidase_2" amino acids 319 to 371 (53 residues), 23 bits, see alignment 1.4e-08 amino acids 404 to 518 (115 residues), 22.9 bits, see alignment E=1.6e-08 PF13442: Cytochrome_CBB3" amino acids 553 to 635 (83 residues), 43.8 bits, see alignment E=6.7e-15 PF00034: Cytochrom_C" amino acids 554 to 636 (83 residues), 44.1 bits, see alignment E=1.1e-14

Best Hits

KEGG orthology group: K00368, nitrite reductase (NO-forming) [EC: 1.7.2.1] (inferred from 65% identity to gpb:HDN1F_11850)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.7.2.1

Use Curated BLAST to search for 1.7.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (659 amino acids)

>LRK54_RS10265 multicopper oxidase domain-containing protein (Rhodanobacter denitrificans FW104-10B01)
MSVPDSGKPAPSTWPAVAGTALRVAFGLIWAVSAALTWTADFANHYVGYLHNAATGQPAW
SGWWFELWIGLVTPHVGFFVWATRIAETLLALALLLGFARKITYVVGILFSLLIWSTAEG
FGGPYSVGANNIGAAISYVLIFAALIVINLRSGPSPYSLDYLIERRWPSWRRLADWNDTL
PLTEVHPLPWRVQGPALAGVLILVALLLAGLHSALNVKSASPQAAAAAVTPLSLASSQPI
GKARDARLPPLQEGGSVAVDIAVSDQSVEIASGVQYQAWTFGKSVPGPVIHVRQGQTVNV
KLTNHGTMQHSIDFHSAITPPSLHYVDIMPGESIAFSFVAKVPGAFLYHCGTPPVLLHIG
NGMYGAIIVDPATPLPPAAESYVLVQGEWYTQQVSGKLMAGNYEKMQQMRPDEVVFNGAA
FQYRDHPLTAKPGDLVRLYVVNAGPSLWSSFHVIGAIFDKVYPGGNPAQAIDGVSTWSVG
PGEGAVFDLKLDEAGHYPFVDHAMAHMQLGAQGVLLVGSPDEAAAKPPVSKAPVAAAPAT
PPPAASGPYTFDPARGASLYAANCAACHQATGLGLPGAFPPLKDNVAVQDADPAKHIEVI
LKGLQGLVINGTSYPTAMPPFAAALNDADIANIANHERSSWGNQGKLITADQVKAARGK