Protein Info for LRK54_RS08565 in Rhodanobacter denitrificans FW104-10B01

Annotation: hydroxymethylglutaryl-CoA reductase, degradative

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00532: hydroxymethylglutaryl-CoA reductase, degradative
  • amino acids 34 to 417 (384 residues), 401.3 bits, E=5.6e-124
• PF00368: HMG-CoA_red
  • amino acids 43 to 417 (375 residues), 370.2 bits, E=1.8e-114
• TIGR00549: mevalonate kinase
  • amino acids 481 to 755 (275 residues), 245.6 bits, E=6.8e-77
• PF00288: GHMP_kinases_N
  • amino acids 561 to 626 (66 residues), 46.3 bits, E=6.8e-16
• PF08544: GHMP_kinases_C
  • amino acids 693 to 772 (80 residues), 63.8 bits, E=2.4e-21

Predicted SEED Role

"Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis or Leucine Degradation and HMG-CoA Metabolism (EC 1.1.1.34)

MetaCyc Pathways

• superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (9/10 steps found)
• mevalonate pathway I (eukaryotes and bacteria) (6/7 steps found)
• isoprene biosynthesis II (engineered) (6/8 steps found)
• mevalonate pathway II (haloarchaea) (4/7 steps found)
• mevalonate pathway IV (archaea) (4/8 steps found)
• mevalonate pathway III (Thermoplasma) (3/8 steps found)
• superpathway of ergosterol biosynthesis I (8/26 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (25/56 steps found)
• superpathway of cholesterol biosynthesis (8/38 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.34

Protein Sequence (780 amino acids)

>LRK54_RS08565 hydroxymethylglutaryl-CoA reductase, degradative (Rhodanobacter denitrificans FW104-10B01)
MDSLPATGQADSPAATPADDTPCDRAASAPEHPARLPGFHRLAVTERLQLLRSRGLLTQA
DHRALTSGAQRLEPAQADKMIENVIGVMGLPVGLGLNFLINGKDYVVPLVVEEPSIVAAL
SAAAKLVRGCGGFTTASDRPLLIGQVQLTGLAHSGKARTALLQRRDEIINLANSLHPNMV
ARGGGVADVEVLIHAAPDGGPDMLVLHLLVDTCDAMGANLVNTMCEGVAPLAEAITGGKA
CLRILSNLTDRALVRASAVIPAHALAGKGHDGGQVRDGIILANDLALVDPYRAATHNKGV
MNGVDAVALATGNDWRALEAAVHAYAARGQGYRALTRWSRNAQGDLVGSIELPLKVGTVG
GSLQANPMVAINHRLLGSPGARELAEVMAAVGLAQNFSALRALVTDGIQQGHMTLHARSV
ALAAGATPPMFEQVVERLLADGEIKLWKAQLIVAELGGQAAPGQAASGHPRAGTQEWAAG
HGKVILLGEHAVVYGRHAIAAPLPLAIRARVEDAHDGTTLLIPRWGIEQRLPQQPAHPGS
FLQSLTLLLQRLGLDRRALRIQVAPEMPRAMGLGGSAALAVAVIRALDRHCALGLDDASV
CALAFECETIAHGTPSGIDNTVATHGEALLYRRGEPATIRPLALKQPLPLVIGLSGSESL
TARMVARVRQAWRQHPARYERIFDEIDVLTRHALDALQAHDLGELGELMNICQGQLNALQ
VSSREIEELVQLAREHGALGAKLTGGGGGGAVIALCPDGGARVVRAMRDAGYQALEVSFG