Protein Info for LRK54_RS04535 in Rhodanobacter denitrificans FW104-10B01

Annotation: FAD-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 699 PF00724: Oxidored_FMN" amino acids 9 to 337 (329 residues), 225.9 bits, see alignment E=2.3e-70 PF07992: Pyr_redox_2" amino acids 387 to 624 (238 residues), 38.4 bits, see alignment E=2.5e-13 PF13450: NAD_binding_8" amino acids 390 to 432 (43 residues), 33 bits, see alignment 1.5e-11

Best Hits

KEGG orthology group: None (inferred from 60% identity to tpr:Tpau_0381)

MetaCyc: 50% identical to 6-hydroxypseudooxynicotine dehydrogenase (Agrobacterium tumefaciens S33)
1.4.98.M1 [EC: 1.4.98.M1]

Predicted SEED Role

"Histamine dehydrogenase"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.98.M1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (699 amino acids)

>LRK54_RS04535 FAD-dependent oxidoreductase (Rhodanobacter denitrificans FW104-10B01)
MRDPRHDILFEPVKIGPVTAKNRFFQVPHCNGMGHAMPLAHAAMREMKAAGGWAVVSTEE
CEIHPSGDLTPYVEARLWDDRDIPALALMCDKVHAHGALAALELSHNGPTASNLYSREVL
IAPSHQPTKYGYPHQARAMTKHDIREYRRWHREAAIRGKRAGMDIIYVYAAHDLSLAMHF
LQRRRNQRGDEYGGSLENRVRLLREVLQDTKEAVGDTCAVALRFAVEEGLGPGGVELAEA
KEIVGMLAELPDLWDVNLAAWYNDSVPSRFAGEGAQEPFIAFVKQATSKPVVGVGRFTSP
DTMVAQLKRGVLDLIGCARPSIADPFLPQKIEQGRSDDIRECIGCNVCVSGDMTISPIRC
TQNPTMGEEWRKGWHPERIAPKRSAARVLVVGAGPAGLEAARALGQRGYEVSLAEARKEL
GGRVSRESRLPGLAEWARVRDWRVGQIHKLANVAVYLDSPLGAQDVLDFGAEHVVLATGC
HWRRDGGGRSHGSTIDGFAGNPRVFTVDDLMGGRLPEGKVVVFDDDGYYHASVAAELLRR
RGGEVIHLTPEDSLAPWTLNTLDYRHMRKRMAALGIEALVSHDIVGYAGTTLAVEDVWTH
RQRELTCDAVLTVTARLPDDALYQDLCRREAEWTDAGIRSVRCIGDAEAPGLIAHAVYAG
HRYARELEEPAVGEVAFKRHFHTADAGDLLRETPVQQAR