Protein Info for IAI47_18180 in Pantoea sp. MT58

Annotation: UDP-N-acetylmuramate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00179: UDP-N-acetylenolpyruvoylglucosamine reductase
  • amino acids 12 to 332 (321 residues), 351.6 bits, E=1.6e-109
• PF01565: FAD_binding_4
  • amino acids 24 to 152 (129 residues), 76.9 bits, E=1.3e-25
• PF02873: MurB_C
  • amino acids 209 to 332 (124 residues), 105.7 bits, E=1.2e-34

Best Hits

Swiss-Prot: 63% identical to MURB_SHIFL: UDP-N-acetylenolpyruvoylglucosamine reductase (murB) from Shigella flexneri

KEGG orthology group: K00075, UDP-N-acetylmuramate dehydrogenase [EC: 1.1.1.158] (inferred from 94% identity to pva:Pvag_3452)

MetaCyc: 63% identical to UDP-N-acetylenolpyruvoylglucosamine reductase (Escherichia coli K-12 substr. MG1655)
UDPNACETYLMURAMATEDEHYDROG-RXN [EC: 1.3.1.98]

Predicted SEED Role

"UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158)" in subsystem Peptidoglycan Biosynthesis or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 1.1.1.158)

MetaCyc Pathways

• peptidoglycan recycling I (14/14 steps found)
• peptidoglycan biosynthesis I (meso-diaminopimelate containing) (12/12 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) (8/8 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) (7/8 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing) (6/8 steps found)
• peptidoglycan biosynthesis III (mycobacteria) (11/15 steps found)
• peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
• peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
• peptidoglycan biosynthesis V (β-lactam resistance) (11/17 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism
• Peptidoglycan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.158 or 1.3.1.98

Protein Sequence (345 amino acids)

>IAI47_18180 UDP-N-acetylmuramate dehydrogenase (Pantoea sp. MT58)
MSSQHPSLKADNTLGLEVHTQKRIVAETPAAILAAWQASQRDQTPFMVLGEGSNVLFLDD
FAGTVVLNRIKGINIQDEYEYWKLHVGAGENWHQLVKSTLEKGITGLENLALIPGMTGSA
PIQNIGAYGVELKDVCEYVDVLNLDSGETERLDREACEFGYRDSIFKHRYQRGYVIVAVG
IILPKQWQPVLTYGDLKTLNPVTASAWDVYHAVCQMRQSKLPDPKVTGNVGSFFKNPVVT
EAQCSALLAHFPAMPHYLMPNGETKLAAGWLIDQCQLKGYRIGGAAVHQQQALVLINADN
ATPDDIVALAKTVRAKVGEKFDVWLEPEVRFIQAQGECNAVGVIA