Protein Info for IAI47_01515 in Pantoea sp. MT58

Annotation: zinc/cadmium/mercury/lead-transporting ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 761 transmembrane" amino acids 156 to 175 (20 residues), see Phobius details amino acids 181 to 198 (18 residues), see Phobius details amino acids 213 to 236 (24 residues), see Phobius details amino acids 379 to 400 (22 residues), see Phobius details amino acids 410 to 435 (26 residues), see Phobius details amino acids 713 to 730 (18 residues), see Phobius details amino acids 736 to 757 (22 residues), see Phobius details PF00403: HMA" amino acids 77 to 133 (57 residues), 39.5 bits, see alignment 1.2e-13 TIGR01512: cadmium-translocating P-type ATPase" amino acids 209 to 758 (550 residues), 505.9 bits, see alignment E=1.7e-155 TIGR01525: heavy metal translocating P-type ATPase" amino acids 209 to 756 (548 residues), 576.4 bits, see alignment E=1.2e-176 TIGR01494: HAD ATPase, P-type, family IC" amino acids 233 to 733 (501 residues), 241.3 bits, see alignment E=2.4e-75 PF00122: E1-E2_ATPase" amino acids 260 to 440 (181 residues), 159.2 bits, see alignment E=1.6e-50 PF00702: Hydrolase" amino acids 460 to 667 (208 residues), 107.8 bits, see alignment E=1.9e-34 PF08282: Hydrolase_3" amino acids 646 to 692 (47 residues), 24.3 bits, see alignment 4.8e-09

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 94% identity to pva:Pvag_3017)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (761 amino acids)

>IAI47_01515 zinc/cadmium/mercury/lead-transporting ATPase (Pantoea sp. MT58)
MHQHHACGCGKPRASHAAAKPLCQVRQARPLSLSIHAATPVTADTAGCCCDSNSSPGNDA
DAAEESDRRGSWPFSWQVSGMDCPSCARTIETAVRQVKGVTDARVLFSSEKLVVNADQDV
QNAVEQAVKKAGFQVAIPSASSPATATSPGWQQNRMLILLALLVLVSSVVSQFAPAWGDR
LFVLTTLVGLIPVARGAWQRIRSGSPFTIETLMTLASAGALIIGAHAEAAMVLVLFQLGE
QLESYAASRARSGVTSLMALRPESAIRLEQGKRREVPLAALQPGDVIEVAAGSRLPVDGR
LISPLASFDESALTGESLPVTRASGEKILAGATSVDRQVMLEVVSKPGESAIDRILQLIE
EAETHRAPVERFIDQFSRIYTPLVMLLSLLVMVVPPLLFAGDWQPWIYKGLTLLLIGCPC
ALVISTPAAITSGLAAAARQGALIKGGAALERLSSLRRMAFDKTGTLTLGKPQLTHILRF
GEASESEMLALSAAAEQGATHPLASAIVAAAQARELVIPDALDQQVQAGRGIRAQVSGQQ
IQLLTPGHAPGLTPKQNAQIAQQEAEGETLVVLMRDGDALGALALRDQLRDDAVEALKAL
KKLGIESLMLTGDNPRAAATIARQLDIDYRASLLPADKVAAIRELSQQQPLAMVGDGIND
APAMKAATLGIAMGSGTDVALEAADAALTRNQLSNLAPMIALARRTRRIIRQNIGIALGL
KAIFLVTTLMGLTGLWLAVLADSGATALVTANALRLLRRRA