Protein Info for HSERO_RS17765 in Herbaspirillum seropedicae SmR1
Annotation: coproporphyrinogen III oxidase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 74% identical to HEM6_METFK: Oxygen-dependent coproporphyrinogen-III oxidase (hemF) from Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
KEGG orthology group: K00228, coproporphyrinogen III oxidase [EC: 1.3.3.3] (inferred from 100% identity to hse:Hsero_3559)MetaCyc: 62% identical to coproporphyrinogen III oxidase (Escherichia coli K-12 substr. MG1655)
Coproporphyrinogen oxidase. [EC: 1.3.3.3]
Predicted SEED Role
"Coproporphyrinogen III oxidase, aerobic (EC 1.3.3.3)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 1.3.3.3)
MetaCyc Pathways
- superpathway of heme b biosynthesis from glutamate (9/10 steps found)
- superpathway of heme b biosynthesis from glycine (6/8 steps found)
- heme b biosynthesis I (aerobic) (3/4 steps found)
- heme b biosynthesis V (aerobic) (3/4 steps found)
- superpathway of heme b biosynthesis from uroporphyrinogen-III (4/6 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (3/9 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (3/9 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.3.3.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See D8IQC6 at UniProt or InterPro
Protein Sequence (306 amino acids)
>HSERO_RS17765 coproporphyrinogen III oxidase (Herbaspirillum seropedicae SmR1) VTTHSNASTNTAAVKAYLQDLQQRIVAALEAADGKSFLSDSWERPEGGGGTSRLLEEGNL LERGGVGFSHVMGKNLPPSAAANRPHLAGRAWEAMGVSLVLHPRNPYVPTVHMNVRFFTT HAEGEEAVWWFGGGMDLTPYYGVEDDARHFHRTCRDALQPYGDELYPRFKTWCDDYFYLK HRKEPRGVGGIFFDDFNALPFEQAFAMQRSVGDAFLAAYLPIVAARRDTPYGERERDFQA YRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPLVKWRYDWHPEPGSPEAALYSDFL VHKEWL