Protein Info for HSERO_RS13915 in Herbaspirillum seropedicae SmR1

Annotation: 2-dehydro-3-deoxyphosphooctonate aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 284 PF00793: DAHP_synth_1" amino acids 8 to 273 (266 residues), 243 bits, see alignment E=1.5e-76 TIGR01362: 3-deoxy-8-phosphooctulonate synthase" amino acids 13 to 275 (263 residues), 403.9 bits, see alignment E=1.2e-125

Best Hits

Swiss-Prot: 87% identical to KDSA_CUPNH: 2-dehydro-3-deoxyphosphooctonate aldolase (kdsA) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K01627, 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC: 2.5.1.55] (inferred from 100% identity to hse:Hsero_2771)

MetaCyc: 49% identical to 3-deoxy-8-phosphooctulonate synthase subunit (Arabidopsis thaliana col)
3-deoxy-8-phosphooctulonate synthase. [EC: 2.5.1.55]

Predicted SEED Role

"2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase (EC 2.5.1.55)" in subsystem KDO2-Lipid A biosynthesis (EC 2.5.1.55)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.55

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IYT1 at UniProt or InterPro

Protein Sequence (284 amino acids)

>HSERO_RS13915 2-dehydro-3-deoxyphosphooctonate aldolase (Herbaspirillum seropedicae SmR1)
MKLCGFDVGLDHPFFLIAGTCVIESEQMALDTAGTLKEITAELGIPFIYKSSFDKANRSS
GSSFRGLGMEKGLEILAKVKKEIGVPVLTDIHEIDEIKPVAAVVDVLQTPAFLCRQTDFI
RACAQSGKPVNIKKGQFLAPHDMVNVIDKARAAAKEAGLPTDQFMACERGVSFGYNNLVS
DMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAIAVGISGVFMETH
PNPAEAKSDGPNAVPLARMKDLLGTMIDLDRIVKKAGFLENHFS