Protein Info for HSERO_RS13005 in Herbaspirillum seropedicae SmR1

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 transmembrane" amino acids 25 to 46 (22 residues), see Phobius details amino acids 52 to 72 (21 residues), see Phobius details amino acids 84 to 103 (20 residues), see Phobius details amino acids 124 to 147 (24 residues), see Phobius details amino acids 159 to 181 (23 residues), see Phobius details PF02518: HATPase_c" amino acids 321 to 434 (114 residues), 65.2 bits, see alignment E=3.5e-22

Best Hits

KEGG orthology group: K15011, two-component system, sensor histidine kinase RegB [EC: 2.7.13.3] (inferred from 100% identity to hse:Hsero_2598)

Predicted SEED Role

"Sensor histidine kinase PrrB (RegB) (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IXJ2 at UniProt or InterPro

Protein Sequence (443 amino acids)

>HSERO_RS13005 histidine kinase (Herbaspirillum seropedicae SmR1)
MFSSPRLRSPASPFPTQHVLLSRLFWLRWAMVAGELLVLAGAHGWLHIALPVPQLLALIG
LQALLNGATWLRLRWTRPAEQRELFLQLLLDLAVLTALLYFSGGSTNPFVSFYLPALAAG
AASLAWPYALLLALCALGAYSGLVYVYEPLHIHDQGQAMAYHLAGMWINFSISALLITWF
VSRIAAAVRSRETELARARERQLQSQRILALGTQAAGAAHALNTPLSTVAVIAGELRRDM
ATQPALAAYDEELRVVEEQIAVCKAALESMRQDADAQTRNEDSAPITPWLTTLLEGWRLR
HPAVLLSAEVHQPGWVAARLEDLSQILLTLLDNAAHAVRERGSEGRVSIRMRAADEPAGR
PAQKAAIIEIADNGSGIAPELLQRLGRAPVASSSGGSGIGLMLAFASAAHLGGKLRLYST
PGQGTCAELRLPLSAMPSPGPAD