Protein Info for HSERO_RS12905 in Herbaspirillum seropedicae SmR1

Annotation: peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 802 PF02190: LON_substr_bdg" amino acids 12 to 201 (190 residues), 199.1 bits, see alignment E=2.1e-62 TIGR00763: endopeptidase La" amino acids 13 to 771 (759 residues), 999.8 bits, see alignment E=5.7e-305 PF00004: AAA" amino acids 352 to 490 (139 residues), 75.3 bits, see alignment E=1.7e-24 PF07728: AAA_5" amino acids 352 to 485 (134 residues), 32.1 bits, see alignment E=2.7e-11 PF05362: Lon_C" amino acids 570 to 772 (203 residues), 326.7 bits, see alignment E=1.3e-101 PF13541: ChlI" amino acids 632 to 740 (109 residues), 30.1 bits, see alignment E=9.8e-11

Best Hits

Swiss-Prot: 70% identical to LON_VIBPA: Lon protease (lon) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 83% identity to bml:BMA10229_A3350)

MetaCyc: 70% identical to Lon protease (Escherichia coli K-12 substr. MG1655)
Endopeptidase La. [EC: 3.4.21.53]

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IXH5 at UniProt or InterPro

Protein Sequence (802 amino acids)

>HSERO_RS12905 peptidase (Herbaspirillum seropedicae SmR1)
MTTPILTEQSQLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEQGKSIMLAAQKAAA
KDEPSAEDIYEIGCVANILQMLKLPDGTVKVLVEGAQRARIHHISELDTHFVADLTPVES
EQGDDAEVEAMRRTIVQQFDQYVKLNKKIPPEILTSLAGIDDAGRLADTIAAHLPLKLEQ
KQVILEIFNVAKRYEHLLGQLEGELDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQK
ELGEGEDGADLEELEKKIAAAKMPKEALEKAQSELKKLKLMSPMSAEATVVRNYIDTLVA
LPWKKKSKVNNDLTNAEKVLEGDHYGLEKVKERILEYLAVQQRVDKLKAPILCFVGPPGV
GKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNPLF
LLDEIDKLGMDFRGDPSSALLEVLDPEQNHTFSDHYIEVDFDLSDVMFVATSNSFNIPPA
LLDRMEVIRLSGYTEDEKTSIAQRYLLPKQIKNNGLKEGEISVAESAIRDIIRYYTREAG
VRSLEREVSKICRKVVKLLLLKKQEKKVTVTSRNLDKFLGVRRFDFGIAEKENQIGQVVG
LAWTEVGGDLLTIEAVNMPGKGQIIRTGTLGDVMKESIEAARTVVRSRARKLGIKNEVFE
KSDIHIHVPEGATPKDGPSAGIAMTTALVSIFSGIPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGIKTVLIPEQNVKDLAEIPDNVKNKLEIIPVRWIDKVLEVALERQPVPLSE
DEAIVEAAVAPKEGATDPVVKH