Protein Info for HSERO_RS12535 in Herbaspirillum seropedicae SmR1

Annotation: dihydropteridine reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 397 transmembrane" amino acids 266 to 286 (21 residues), see Phobius details PF00042: Globin" amino acids 27 to 133 (107 residues), 45.1 bits, see alignment E=2e-15 PF00970: FAD_binding_6" amino acids 159 to 257 (99 residues), 42.9 bits, see alignment E=7.9e-15 PF00175: NAD_binding_1" amino acids 268 to 372 (105 residues), 61.3 bits, see alignment E=2e-20

Best Hits

Swiss-Prot: 67% identical to HMP_BURST: Flavohemoprotein (hmp) from Burkholderia sp. (strain TH2)

KEGG orthology group: K05916, nitric oxide dioxygenase [EC: 1.14.12.17] (inferred from 100% identity to hse:Hsero_2508)

Predicted SEED Role

"Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)" in subsystem Bacterial hemoglobins or Flavohaemoglobin or Glutaredoxins (EC 1.14.12.17)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.12.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IWI7 at UniProt or InterPro

Protein Sequence (397 amino acids)

>HSERO_RS12535 dihydropteridine reductase (Herbaspirillum seropedicae SmR1)
MLTDAQLAIVKSTVPLLESGGEALTTHFYKMLMRDYPQVRPLFNRAHQASGDQPRALANG
VLMYARHIDRLEELGPLAAQIINKHVAVQVLPEHYPMVGDCLLRAIREVLGAEIATDAVI
DAWAAAYGQLADILIGAERQQYEAKAQAPGGWSGARNFIVSRKVAESEEITSFHFVPQDG
GELLDFAPGQYIGLRMVVDGEEQRRQYSLSALLRQAGQPPQYRISVKREPGGKVSRQLHD
QIHVGSVVELFPPAGEFTLMASDKPLALISGGVGITPMMSMLAAALPSGRPIHFIHAARH
GGVHAFRRQLEELAARHPQLQLRFCYEQPRQGDAAPHATGLIERSLLQQWLPGNPDLDAY
FVGPKSFMKAIKRQLAELGVPAAQSRYEFFGPAASLD