Protein Info for HSERO_RS10905 in Herbaspirillum seropedicae SmR1

Annotation: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00243: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • amino acids 2 to 384 (383 residues), 512.4 bits, E=3.7e-158
• PF02670: DXP_reductoisom
  • amino acids 4 to 132 (129 residues), 159.4 bits, E=1.1e-50
• PF08436: DXP_redisom_C
  • amino acids 146 to 234 (89 residues), 129.1 bits, E=8.5e-42
• PF13288: DXPR_C
  • amino acids 266 to 382 (117 residues), 144.4 bits, E=2.6e-46

Best Hits

Swiss-Prot: 74% identical to DXR_JANMA: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) from Janthinobacterium sp. (strain Marseille)

KEGG orthology group: K00099, 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC: 1.1.1.267] (inferred from 100% identity to hse:Hsero_2184)

MetaCyc: 54% identical to 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli K-12 substr. MG1655)
1-deoxy-D-xylulose-5-phosphate reductoisomerase. [EC: 1.1.1.267]

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)" in subsystem Isoprenoid Biosynthesis or polyprenyl synthesis (EC 1.1.1.267)

MetaCyc Pathways

• methylerythritol phosphate pathway II (8/9 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (10/12 steps found)
• taxadiene biosynthesis (engineered) (10/13 steps found)
• methylerythritol phosphate pathway I (7/9 steps found)
• isoprene biosynthesis I (7/10 steps found)
• superpathway of ergosterol biosynthesis II (11/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.267

Sequence Analysis Tools

See D8IU21 at UniProt or InterPro

Protein Sequence (390 amino acids)

>HSERO_RS10905 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Herbaspirillum seropedicae SmR1)
MQSISILGSTGSIGVSTLDVVARHPDRYRVYALSAHSRVAELAQQCAQFRPQVAVVGTAA
AAAELQFLLAARAIKTEVAYGPQALCDIASANGCDMVMAAIVGAAGLASTLAAARAGKKI
LLANKEALVISGQLLMDAVAAHGASLLPIDSEHNAIFQCLPPGYTRSMSAHGVEKILLTA
SGGPFLTRDVGTLDTVTVEEAVAHPKWVMGRKISVDSATMMNKGLEVIEAHWLFGAPADK
IEVVIHPQSVIHSMVSYADGSVLAQLGNPDMRTPIANALAYPERIASGVAPLDLAQIAQL
SFSEPDFQRFPCLKLAYDALRAGGTLAAILNAANEVAVQAFLGRRIGFGKIAPLIDEVMS
AIPNRQADDIDALLEQDRQARSHAEHLISR