Protein Info for HSERO_RS09815 in Herbaspirillum seropedicae SmR1

Annotation: sodium:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 546 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 33 to 51 (19 residues), see Phobius details amino acids 59 to 78 (20 residues), see Phobius details amino acids 88 to 111 (24 residues), see Phobius details amino acids 117 to 136 (20 residues), see Phobius details amino acids 149 to 174 (26 residues), see Phobius details amino acids 186 to 208 (23 residues), see Phobius details amino acids 229 to 261 (33 residues), see Phobius details amino acids 281 to 299 (19 residues), see Phobius details amino acids 306 to 329 (24 residues), see Phobius details amino acids 337 to 359 (23 residues), see Phobius details amino acids 370 to 389 (20 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 11 to 386 (376 residues), 255.3 bits, see alignment E=8.9e-80 TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 15 to 296 (282 residues), 241 bits, see alignment E=8.5e-76 PF02254: TrkA_N" amino acids 415 to 529 (115 residues), 94.3 bits, see alignment E=6.5e-31

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 100% identity to hse:Hsero_1966)

Predicted SEED Role

"Binding-protein-dependent transport systems inner membrane component:ATP/GTP-binding site motif A (P-loop) :TrkA-N:Potassium e" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8ISC6 at UniProt or InterPro

Protein Sequence (546 amino acids)

>HSERO_RS09815 sodium:proton antiporter (Herbaspirillum seropedicae SmR1)
MPHHTPLIATIVAGLVLAFIFGTLAHRLKMPPLVGYLVAGIAIGPFTPGFVGDADLAQEL
AEIGVILLMFGVGLHFSLKDLLSVKNIAIPGAVAQITIATLLGMALGWLLGWPVGEGFLF
GLALSVASTVVLLKALQERRLVETQRGRIAVGWLIVEDIAMVLALVLIPALSGILGGKGE
ALSGNAVLLTLGITLGKVVAFAAVMLIVGRRVIPWILERIADTGSRELFRLAVLAIALGF
ALGSAYVFGVSFALGAFFAGMILSESELSHRAAEESLPLRDAFSVLFFVSVGMLFDPSIV
AREPLLVLATVLIIVVGKSLGALLIVRAFGYPNGTALTISASLAQIGEFSFILATLGLSL
DLLSPMARDLILGGAILSILLNPLLFSLLDRYEARQPKAPQGGDEPQKVELQDHVVLVGF
GRVGRGIGEQLRAQGKPFVVIEAQLENLEALRAAGVPALYGNAAQSELLQAAAIDRARWL
LVAIPEVFEAGQVIENALELNPGLQVVARAHSDAEIEHLEKHGAQRVIMGEREIARGMLE
LVGQGA