Protein Info for HSERO_RS08100 in Herbaspirillum seropedicae SmR1
Annotation: nicotinate phosphoribosyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 76% identical to PNCB_BURPS: Nicotinate phosphoribosyltransferase (pncB) from Burkholderia pseudomallei (strain K96243)
KEGG orthology group: K00763, nicotinate phosphoribosyltransferase [EC: 2.4.2.11] (inferred from 100% identity to hse:Hsero_1629)Predicted SEED Role
"Nicotinate phosphoribosyltransferase (EC 2.4.2.11)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation or Redox-dependent regulation of nucleus processes (EC 2.4.2.11)
MetaCyc Pathways
- NAD salvage pathway I (PNC VI cycle) (6/7 steps found)
- NAD salvage pathway V (PNC V cycle) (4/5 steps found)
- NAD salvage (plants) (6/11 steps found)
- superpathway of NAD biosynthesis in eukaryotes (7/14 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Nicotinate and nicotinamide metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.11
Use Curated BLAST to search for 2.4.2.11
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See D8IQN1 at UniProt or InterPro
Protein Sequence (391 amino acids)
>HSERO_RS08100 nicotinate phosphoribosyltransferase (Herbaspirillum seropedicae SmR1) MIITSLLDTDLYKFTMMQVVLHHFPGAQVEYRFKCRNENVDLRPYVDEIRAEIAALCRLR FKEDELNYLRSLRFIKSDFVDFLDLFHLNEKYITVQPDPAGNGEIEISVKGPWLHTIMFE VPVLAIVNEVYFRATQRSPDLEEGRARLRKKMSVITDDPELAGCKIADYGTRRRFSRSWH AEVIDEMKQHMGDHFAGTSNVMYAMQHDLTPLGTMAHEYLQACQALGPRLRDSQTFAFEM WAREYRGDLGITLSDVYGMDAFLRDYDMYFCKLFDGARHDSGDPFEWGERLIQHYRDNRV DPSSKVLVFSDSLDFDKVRALYLRFKDRAKVAFGVGTNLTNDLGYTPLQVVMKMVRCNGQ PVAKLSDTPSKNMCDDPAYVNYLRQVFQIKA