Protein Info for HSERO_RS07645 in Herbaspirillum seropedicae SmR1

Annotation: RND transporter MFP subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 518 transmembrane" amino acids 25 to 43 (19 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 86 to 414 (329 residues), 241.4 bits, see alignment E=5.8e-76 PF16576: HlyD_D23" amino acids 109 to 333 (225 residues), 38.7 bits, see alignment E=1e-13 PF13533: Biotin_lipoyl_2" amino acids 111 to 159 (49 residues), 57.4 bits, see alignment 1.5e-19 PF13437: HlyD_3" amino acids 113 to 160 (48 residues), 26 bits, see alignment 1.9e-09

Best Hits

KEGG orthology group: K07799, putative multidrug efflux transporter MdtA (inferred from 100% identity to hse:Hsero_1520)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IPY9 at UniProt or InterPro

Protein Sequence (518 amino acids)

>HSERO_RS07645 RND transporter MFP subunit (Herbaspirillum seropedicae SmR1)
MTNTPNPHPPSPSNASARGSILRRWWFWVLVAALAAGGGYKMWSKKKAEQEQMAAMGGPG
GRPGPGAAGARRPGGPGAFGPQTMPVGVAKARLQDVNVFLNGLGAVTPTATATVRARVDG
QLMKLHYKEGQVVKAGDLLAEIDPRSLQAALTQAEGQLARDRALLASARLDLKRYQTLLA
QDSIASQQVDTQVALVKQYEGTVKADEGNVASARLQLSFTRVTAPISGRLGLRQADVGNN
VTTSDTNGLVIITQLQPITAIFSIPEDNIPKVLQQLQSGRKLPAQAWDREQKNKLADGVL
LTIDNVVDATTGTVKLKAQFPNTDYALFPSQFVNIRLQLNTEQGATVIPTAAIQRGSKGL
FVYVVKDDSSVTVRPVKTGPVQDDLTVITDGVSAGETVVIDGIDRLREGAKVEAVARGGA
DDPANKLTTENPERRHGKRGQGNPGAQAGAGGDAGQGAQGGMSPEERQKRWAELNKRIDA
GEFGEEIKKLPEDQRRQKMMELRRQREAAGNGNGNAAK