Protein Info for HSERO_RS02965 in Herbaspirillum seropedicae SmR1
Annotation: gamma-glutamyl phosphate reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 84% identical to PROA_JANMA: Gamma-glutamyl phosphate reductase (proA) from Janthinobacterium sp. (strain Marseille)
KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 100% identity to hse:Hsero_0592)MetaCyc: 45% identical to glutamate-5-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]
Predicted SEED Role
"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)
MetaCyc Pathways
- L-citrulline biosynthesis (7/8 steps found)
- L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
- superpathway of L-citrulline metabolism (9/12 steps found)
- L-Nδ-acetylornithine biosynthesis (5/7 steps found)
- L-ornithine biosynthesis II (2/3 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.41
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See D8IYF1 at UniProt or InterPro
Protein Sequence (422 amino acids)
>HSERO_RS02965 gamma-glutamyl phosphate reductase (Herbaspirillum seropedicae SmR1) MENIDLYMNRIGQQARAASRAMARADTAAKNQALLLIAAAIRRDADALRAANALDLEAAR ANGLAEAMLDRLTLSDKAIATMAEGLEQIASLPDPIGEISNMKYRPTGIQVGQMRVPLGV IGIIYEARPNVTVDAAGLCIKSGNATILRGGSEAIHCNQALAKLVKEGLAGAGLPEQAVQ VVETTDRAAVGALITMQEYVDVIVPRGGKGLIERLMKEAKVPMIKHLDGICHVYIDDKAD TRKALDVAFNAKCHRYGTCNTMETLLVARNIAAAILPPLSELYRVKEVELRCDAEAAEIL AGYPLLKAATEEDWDTEYLAPILAVKVVADMDEAIEHINRHSSQHTESIITEDYTRAMRF LREVDSASVMVNASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYIVLGNGQV RQ