Protein Info for HSERO_RS02355 in Herbaspirillum seropedicae SmR1

Annotation: phosphoglucomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 8 to 138 (131 residues), 134.4 bits, E=4.4e-43
• PF02879: PGM_PMM_II
  • amino acids 153 to 250 (98 residues), 96.5 bits, E=2.5e-31
• PF02880: PGM_PMM_III
  • amino acids 255 to 363 (109 residues), 78.8 bits, E=7.4e-26
• PF00408: PGM_PMM_IV
  • amino acids 369 to 447 (79 residues), 44.8 bits, E=2.2e-15

Best Hits

Swiss-Prot: 55% identical to ALGC_PSEAB: Phosphomannomutase/phosphoglucomutase (algC) from Pseudomonas aeruginosa (strain UCBPP-PA14)

KEGG orthology group: K01835, phosphoglucomutase [EC: 5.4.2.2] K01840, phosphomannomutase [EC: 5.4.2.8] (inferred from 100% identity to hse:Hsero_0472)

MetaCyc: 55% identical to phosphomannomutase (Pseudomonas aeruginosa)
Phosphomannomutase. [EC: 5.4.2.8]; Phosphoglucomutase. [EC: 5.4.2.8, 5.4.2.2]

Predicted SEED Role

"Phosphomannomutase (EC 5.4.2.8)" in subsystem Alginate metabolism or Mannose Metabolism (EC 5.4.2.8)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• superpathway of anaerobic sucrose degradation (15/19 steps found)
• colanic acid building blocks biosynthesis (9/11 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• GDP-mannose biosynthesis (3/4 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• sucrose biosynthesis II (5/8 steps found)
• starch degradation V (2/4 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (1/3 steps found)
• glycogen degradation II (3/6 steps found)
• chitin biosynthesis (5/9 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (2/5 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (4/8 steps found)
• glycogen degradation I (4/8 steps found)
• starch degradation III (1/4 steps found)
• starch biosynthesis (5/10 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (7/14 steps found)
• β-(1,4)-mannan degradation (1/7 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• streptomycin biosynthesis (2/18 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Pentose phosphate pathway
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.2

Use Curated BLAST to search for 5.4.2.2 or 5.4.2.8

Sequence Analysis Tools

See D8IXC2 at UniProt or InterPro

Protein Sequence (458 amino acids)

>HSERO_RS02355 phosphoglucomutase (Herbaspirillum seropedicae SmR1)
VTSLSPSIFKAYDIRGIIGKTLDGTVAYRIGQAFGAAALAKGQKKVVIGRDGRLSGPELA
AELARGLQAVGVDVIDLGMVATPMVYFGTHVLDTQSGIMVTGSHNPPDYNGFKMVLAGEA
IHGETIQALYHAIVKGDFPQGAGGYATHDIKAAYIERMLADVKLARPLKIAVDCGNGVAG
AFAGEIYRTLGCEVTELFCEVDGTFPNHHPDPAHPENLQDLIRCLRETDCELGLAFDGDG
DRLGLVTKDGQIIYPDRQLMLFAEDVLTRHPGKEILYDVKCTRHLAPWITARGGRPLMWK
TGHSLVKAKLRETGAPLGGEMSGHIFFKDRWFGFDDGLYAGVRMLELMARQADPSAVLNA
LPQSVSTPELQLKLQEGENVALIGKLQGEASFEGAQEIIAIDGLRVEYPDGFGLARSSNT
TPVVVLRFEAETPEALARIQAQFRQAILAVRPEVALPF