Protein Info for HSERO_RS00375 in Herbaspirillum seropedicae SmR1

Annotation: phosphatidate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01148: CTP_transf_1
  • amino acids 45 to 309 (265 residues), 225.1 bits, E=7.6e-71

Best Hits

KEGG orthology group: K00981, phosphatidate cytidylyltransferase [EC: 2.7.7.41] (inferred from 100% identity to hse:Hsero_0076)

Predicted SEED Role

"Phosphatidate cytidylyltransferase (EC 2.7.7.41)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.7.41)

MetaCyc Pathways

• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• superpathway of phospholipid biosynthesis III (E. coli) (10/12 steps found)
• CDP-diacylglycerol biosynthesis I (4/4 steps found)
• CDP-diacylglycerol biosynthesis II (4/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (9/13 steps found)
• CDP-diacylglycerol biosynthesis III (3/5 steps found)
• type I lipoteichoic acid biosynthesis (S. aureus) (4/17 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism
• Phosphatidylinositol signaling system

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.41

Use Curated BLAST to search for 2.7.7.41

Sequence Analysis Tools

See D8ITW5 at UniProt or InterPro

Protein Sequence (313 amino acids)

>HSERO_RS00375 phosphatidate cytidylyltransferase (Herbaspirillum seropedicae SmR1)
MTAQDTLIALFAGVFAVLALASSVGGLLRWRLAGRNSSVVDNLNARIKAWWWMIGALALA
FWMGKTGVVVLFAFISLQALREFISVTYTRVGDHRALLWCFFVFLPLQYVLIGMDWYGLF
SILIPVYAFLLLPISASLSADTKHFLERAAKVQWGLMICVYCISHVPALLTLAIPGFEGR
NLQLIVFLVLTVQSSDVFQYVWGKLFGKRKLAPQISPSKTLEGLVGGVLTSTAVGAALYW
ITPFNVWQAALVALTINILGFFGGFVLSAIKRDRGLKDWGAMIEGHGGMLDRVDSISFSA
PIFFHILRYWWVP