Protein Info for HMPREF1078_RS17990 in Parabacteroides merdae CL09T00C40

Annotation: family 20 glycosylhydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 770 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 32 to 159 (128 residues), 84.6 bits, see alignment E=2.3e-27 PF00728: Glyco_hydro_20" amino acids 163 to 505 (343 residues), 386 bits, see alignment E=5e-119 PF13290: CHB_HEX_C_1" amino acids 548 to 605 (58 residues), 47.4 bits, see alignment 3.9e-16 PF13287: Fn3_assoc" amino acids 555 to 609 (55 residues), 51.5 bits, see alignment 2.3e-17 PF00754: F5_F8_type_C" amino acids 640 to 745 (106 residues), 31.6 bits, see alignment E=4e-11

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 51% identity to bth:BT_1051)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (770 amino acids)

>HMPREF1078_RS17990 family 20 glycosylhydrolase (Parabacteroides merdae CL09T00C40)
MNRELLFYITAILLCAGILSCNKKEAIATCNYEVVPLPKSITPAKEAPFILSTSTYIGYP
EGNEKLRQTAVFLSGYIREMTGIETEVTADTGSSNSIRLVLDRTAVSSPEGYRLKVGKRD
ITITGSSEAGIFYGIQTLRKSLPVTGQKEISFPAVQILDEPEYRYRGMHLDVGRHFFSTD
FIKKYIDIIALHNLNTFHWHLTDDQGWRIEIKKYPKLTEIGSKRKESLLNDGPGKFDGKP
YGGFYTQEEVKDIIEYAAERYITVIPEIDLPGHITSALAAYPDLGCTGGPYEVATTYGVH
KEVLCVGNEQSLRFAKDVLSEIIELFPSHYIHVGGDECPRDRWQQCPKCQALIHNNGWKD
TKEHKAEDKLQSYFMTEVERFVNSKGRQIIGWDEILEGGLAPNATVMSWRGTENGIKAAE
MQHDVIMTPAGITYFSGRQLLELGGNRGVRRVYDFKICPDTLSEAAAKHIIGVQACLWSE
RIDTPERAEYLILPRLAALSELGWADPEQHDFDAFMDRLYRLITVYDKSHYTYSEHVFQI
TENFRTDTLQDALEISLSTIGNRPIYYTTDGSQPDTASLIYTEPLIIREDTKLKAVIVTT
EDTSSVFEEHIHVNKATFKPSWLANAPHENYTFNGVSTLTDGLQGNQNYNTGRWLGFLKD
MDLTIDLQKSTPVSSVSLTVNVSKGAAVMDATGLEVWCSEDGKEYRKLASASYPVLDKED
KDGIYPHTLSFSVVETRYVRIIARVTSKLPAWHMWPGNPAFLFVDEVCVK