Protein Info for HMPREF1078_RS16235 in Parabacteroides merdae CL09T00C40

Annotation: phosphatidate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 277 transmembrane" amino acids 5 to 24 (20 residues), see Phobius details amino acids 29 to 48 (20 residues), see Phobius details amino acids 60 to 78 (19 residues), see Phobius details amino acids 84 to 102 (19 residues), see Phobius details amino acids 111 to 131 (21 residues), see Phobius details amino acids 144 to 165 (22 residues), see Phobius details amino acids 186 to 205 (20 residues), see Phobius details amino acids 211 to 230 (20 residues), see Phobius details PF01148: CTP_transf_1" amino acids 6 to 274 (269 residues), 189.2 bits, see alignment E=6.7e-60

Best Hits

KEGG orthology group: K00981, phosphatidate cytidylyltransferase [EC: 2.7.7.41] (inferred from 73% identity to pdi:BDI_1855)

Predicted SEED Role

"Phosphatidate cytidylyltransferase (EC 2.7.7.41)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.7.41)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (277 amino acids)

>HMPREF1078_RS16235 phosphatidate cytidylyltransferase (Parabacteroides merdae CL09T00C40)
MKNLIIRALTGIIFVVVLISAIYIHPIFFLILFCIITGLTLWEFGGLVKHYENANLQRTV
NVLGGVYLFIATFVYANGLTDGKIFLPYLLFIMLTMIAELYYKAPNPINNWAFTLFAQVY
CAGSFSILNFIGAEPGTPGVMSYTPLFIMAIFIFVWLDDTGAYLVGSLIGKHKLFERISP
KKSWEGFFGGLILSLASSQAFAWFAPEINRMNWLGLAATVVLFGTWGDLIESLLKRTLGV
KDSGNVLPGHGGMLDRFDSVMLAVPASYIYIELFIRN