Protein Info for HMPREF1078_RS16185 in Parabacteroides merdae CL09T00C40

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 820 PF02190: LON_substr_bdg" amino acids 47 to 241 (195 residues), 159 bits, see alignment E=4.5e-50 TIGR00763: endopeptidase La" amino acids 49 to 810 (762 residues), 928.4 bits, see alignment E=2.2e-283 PF07728: AAA_5" amino acids 390 to 524 (135 residues), 40.9 bits, see alignment E=6.4e-14 PF00004: AAA" amino acids 390 to 527 (138 residues), 89.9 bits, see alignment E=6.1e-29 PF05362: Lon_C" amino acids 608 to 811 (204 residues), 275.9 bits, see alignment E=5.7e-86

Best Hits

Swiss-Prot: 87% identical to LON_PARD8: Lon protease (lon) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 87% identity to pdi:BDI_1874)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (820 amino acids)

>HMPREF1078_RS16185 endopeptidase La (Parabacteroides merdae CL09T00C40)
MKKDKVTMFAEESYNDLDDNIGIVMPILTDCDVDEDFTEGMEKVGEELPILPLRNMVLFP
GVAMPVMIGRPKSMRLIKEAAHKKSLIGVVCQKDMNTEDPKIEDLYATGVVADIVRVLEM
PDGTTTVILQGKKRFQLEELSAYDPYLIGKIKLLEDVMPDKSDREFEALVSTIKDLTIKM
LGAASEPPRDLIFSIKNNKNILYLINFSCCNVPNGSSEKQDLLLIGNLKDRAYRLLFILN
REYQLVELKTSIQMKTHEDINQQQKEYFLQQQIKTIQEELGGNINDLEIRELREKAAKKK
WSLAVAETFEKEVRKLERLHPQSPDFSIQTQYVQAIVNLPWNEYSKDNFNLAHAQKVLDR
DHYGLEKVKERIIEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGKSVAEALHRKYVRVSL
GGLHDEAEIRGHRRTYIGAMSGRIIQNLQKAGTSNPVFILDEIDKVTNDFKGDPASALLE
VLDPEQNNAFHDNYLDIDYDLSKVMFIATANNLNTISQPLLDRMELIEVSGYIMEEKVEI
AARHLVPKQLEIHGLSKGKVKFPKKTLQAIIESYTRESGVRELDKKIAKIMRKLARKLAS
SEELPAQIRPEDLHDYLGAVEYTRDKYQGNNYAGVVTGLAWTAVGGEILFVESSLSKGKG
SKLTLTGNLGDVMKESAMLALEYIHSHAGLFGIDEGMFENWNVHIHVPEGAIPKDGPSAG
ITMVTSLVSAFTQRKVRSNLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKELILCQENK
KDIEEIKPDYLKGLAFHYVDDIRQVVDLALLKEKVANPLF