Protein Info for HMPREF1078_RS15665 in Parabacteroides merdae CL09T00C40

Annotation: aminoacyl-tRNA hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 187 PF01195: Pept_tRNA_hydro" amino acids 4 to 185 (182 residues), 210.6 bits, see alignment E=9.1e-67 TIGR00447: aminoacyl-tRNA hydrolase" amino acids 4 to 186 (183 residues), 178.8 bits, see alignment E=4.5e-57

Best Hits

Swiss-Prot: 87% identical to PTH_PARD8: Peptidyl-tRNA hydrolase (pth) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K01056, peptidyl-tRNA hydrolase, PTH1 family [EC: 3.1.1.29] (inferred from 87% identity to pdi:BDI_0332)

Predicted SEED Role

"Peptidyl-tRNA hydrolase (EC 3.1.1.29)" (EC 3.1.1.29)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.29

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (187 amino acids)

>HMPREF1078_RS15665 aminoacyl-tRNA hydrolase (Parabacteroides merdae CL09T00C40)
MKYLITGLGNIGSEYLGTRHNIGFRVVNALVEDAGVPFTEERYGAIARMRIKNCELIILK
PNTFMNLSGNAVRYWLQKENIPVENLLVIVDDLALPFGTLRLKPKGSDAGHNGLKNIQQL
LGTQEYSRLRFGIGSNFPRGGQINYVLGKFPPEELQEMPEKIKRAVEIIKSFCLAGVQNT
MNQYNNK