Protein Info for HMPREF1078_RS15575 in Parabacteroides merdae CL09T00C40

Annotation: glucosamine-6-phosphate deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01182: Glucosamine_iso
  • amino acids 46 to 267 (222 residues), 68.3 bits, E=9.2e-23
• PF02585: PIG-L
  • amino acids 381 to 556 (176 residues), 61.2 bits, E=1.5e-20

Best Hits

KEGG orthology group: K02564, glucosamine-6-phosphate deaminase [EC: 3.5.99.6] (inferred from 84% identity to pdi:BDI_0238)

Predicted SEED Role

"Glucosamine-6-phosphate deaminase (EC 3.5.99.6)" in subsystem Chitin and N-acetylglucosamine utilization or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 3.5.99.6)

MetaCyc Pathways

• N-acetylglucosamine degradation II (3/3 steps found)
• N-acetylglucosamine degradation I (2/2 steps found)
• superpathway of N-acetylneuraminate degradation (16/22 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (4/7 steps found)
• superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation (3/6 steps found)
• chitin derivatives degradation (3/8 steps found)
• chitin degradation I (archaea) (1/7 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.99.6

Use Curated BLAST to search for 3.5.99.6

Protein Sequence (659 amino acids)

>HMPREF1078_RS15575 glucosamine-6-phosphate deaminase (Parabacteroides merdae CL09T00C40)
MKTDLSSQITLTRIPQRYYRPENAFEHSVLTRLEKIPTNIYESADEGSFAIAKEIADQIR
KKQEIGENFVMAIPGGRSPLSVYKELIRMHKEEQLSFRNVVVFVEYEFFPLVSPSAGNVA
QLKEALLDHIDIALENVYAPDGCMPKDAIIDFCRMYEENIQKAGGLDYILLGVGHASNIM
FNGVGATLSSRTRLVLLEGTARKEASRTFPSLDNVPAGVITMGIATMMKARNVILMAWGE
DKAKIIAKTVEGKVSDAVPSSYLQNHTNAKVVVDLSAAYDLTRISHPWLVTNCEWDNKLI
RRAIVWLCQLTGKPILKLTNKDYSENGLGELLALYGSAYNVNIRVFNDIQHTITGWPGGK
PNADDSNRPERATPYPKKVIIFSPHPDDDVISMGGTFHRLCEQHHDVHVAYETSGNIAVG
DEEVIRYCEYLRDVCAKYTEDETVKKKAEEIIHFLRYEKVEGEKRDVLFMKGTIRREEAR
AGARYSGIKSDDHIHFLDLPFYETGLVKKNDLSEADIAIVKKLLTDVKPDEMFVAGDLAD
PHGTHRVCLNAVLAAIDELKDEEWLKNCRIWMYRGAWAEWEMDHVEMAVPISPEELRHKR
NAILKHQSQAESAPFLGDDERLFWQRAEDRNRATAELYHQLGLASYEAMEAFVQYVPVR