Protein Info for HMPREF1078_RS14015 in Parabacteroides merdae CL09T00C40

Annotation: PepSY-associated TM helix domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 375 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 143 to 164 (22 residues), see Phobius details amino acids 185 to 211 (27 residues), see Phobius details amino acids 342 to 365 (24 residues), see Phobius details PF03929: PepSY_TM" amino acids 7 to 367 (361 residues), 227.8 bits, see alignment E=1.3e-71

Best Hits

KEGG orthology group: None (inferred from 80% identity to pdi:BDI_3404)

Predicted SEED Role

"conserved hypothetical protein, putative iron uptake factor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (375 amino acids)

>HMPREF1078_RS14015 PepSY-associated TM helix domain-containing protein (Parabacteroides merdae CL09T00C40)
MKKFFAKIHLWLSIPFGIIIAIVCLTGAILVFEAEILEFCYPSRYFVKEIKSEPLSPATL
MDTAREQLPDSIKINGIRVSSDPKRTYQLILPGKKAACFINPYTGEITGIDDGKGFFMKI
MRLHRWLLDEYKRDGSFAWGKTIVGYSTLVLAIIIISGLVIWYPRNKKALKNRLKIKTKA
GWFRFLYDLHVSGGFYAALLLLILALTGLTWSFGWYRDAFYTAFGISTTSKQTHAPTSAV
PPKTAGERGSKKHPKTDYTQWAEVLADLQSRYPEYKSISIQDGSATVSTATYGNTRGSDR
YSFDPATGKITEIQLYKDLPKSAKIRGWIYSVHAGTWGGLTTRILSCLVSLLGAVFAITG
YYFWIKKKLRKSKQR