Protein Info for HMPREF1078_RS12145 in Parabacteroides merdae CL09T00C40

Annotation: TolC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 489 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF02321: OEP" amino acids 27 to 260 (234 residues), 53.7 bits, see alignment E=1.2e-18 amino acids 283 to 470 (188 residues), 83.1 bits, see alignment E=1.1e-27

Best Hits

KEGG orthology group: None (inferred from 62% identity to bvu:BVU_3174)

Predicted SEED Role

"Outer membrane protein assembly factor YaeT precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (489 amino acids)

>HMPREF1078_RS12145 TolC family protein (Parabacteroides merdae CL09T00C40)
MKQIIYIAILFLLPLQLQAQKTLTLTLSEAIEMARRNSPEAIAARHAFRASYWNWRSFRA
KQLPSLTLTSDPSLNRSIQSVTLEDGSDKFVHRNQLSVDASLEIQQNIALTGGKVLLKTG
LERLDMFTDNISSYKSTPVVVGYEQDLFGFNDLKWERRIEPIKYEEAKKTYIETLELVAA
YTTNRFFNLATAQTSLEIANYNFAYADTLYRYAQGRYNIGTITENEMLQLELNKLTEQTN
CLNAQIEVDDYIQSLRSYLGISENINLVVIPDDSIPHFTVDVNEAMQLAFQNNPDISAFE
RRRLQSESNVAEAKANRGFKAALYAQFGLTQSNEKLKESYRDPMDQQLVTLGIRIPILDW
GVGKGRVKVAKSNRDKVYTELEQERMDFELNVAKIVKQFNIQAGKVAIAYKTDQTAQRRN
DVARRLYLLGKSTILDLNAAIAEKDNSRRAYIAALYNYWNLYYGLRSLTGYDFEKMIPIT
EDYELLLNN