Protein Info for HMPREF1078_RS12110 in Parabacteroides merdae CL09T00C40

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1266 PF02811: PHP" amino acids 6 to 223 (218 residues), 172.6 bits, see alignment E=1.9e-54 TIGR00594: DNA polymerase III, alpha subunit" amino acids 100 to 1139 (1040 residues), 1110.7 bits, see alignment E=0 PF07733: DNA_pol3_alpha" amino acids 401 to 670 (270 residues), 298.3 bits, see alignment E=1.2e-92 PF17657: DNA_pol3_finger" amino acids 673 to 836 (164 residues), 193.6 bits, see alignment E=3.2e-61 PF14579: HHH_6" amino acids 909 to 998 (90 residues), 110.5 bits, see alignment 7.7e-36

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 70% identity to bfs:BF0641)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1266 amino acids)

>HMPREF1078_RS12110 DNA polymerase III subunit alpha (Parabacteroides merdae CL09T00C40)
MEPFIHLHVHTQYSLLDGQASIDALIDKAQKDGMPAIAVTDHGVMFGIKEFFNKVSKKNG
KPLGAIKDYEKELKELKSKTELTAEEQARLEEIPAKIEEEKKKIFKPIFGCECYCARNGR
HSKLASQNDRSGWHLIVLAKNLNGYKNLIKMVSLSWTEGFYGRPRIDKELLEKYHEDLII
CSACIGGEIPQHILNGRMDKAEESVLWFKNLFGEDYYLEIQRHETHDPNAAQDVYPHQVT
ANKAILELARKHNIKVIATNDVHFVNAEDAEAHDRLICLSTGKDLDDPNRMRYTKQEWMK
TTAEMNTIFSDIPEALSNTLEIADKVEFYSIDHGPIMPTFAIPEDFGTEEEYRQKFTEQD
LFDEFTRDENGNVVLSEEAAHDKIKKLGGYEKLYRIKLEADYLKKITYDGAKICYGDDLN
DEVKERLNFELHIMKTMGFPGYFLIVQDFIRAAREELGVSVGPGRGSAAGSAVAYCLGIT
RIDPIKYDLLFERFLNPDRISLPDIDTDFDDDGRGEVLRWVTEKYGAERVAHIITYGTMA
TKSAIKDVARVQKLPLAESNRLAKLVPDKIPDMKKFKLKDAINYVPELKEAATGNDPLAR
DTLKYAQMLEGNVRNTGVHACGVIIGRYDISDVVPVSTAKDKDTGEEMLVTQYEGSVIEE
TGLIKMDFLGLKTLSIIKEAIENIRLTTGHDLDIDHISLEDPATYKLYCDGKTTGTFQFE
SAGMQKYLKELQPSKFEDLIAMNALYRPGPMDYIPSFIARKQGKEEIKYDIPVMERYLKD
TYGITVYQEQVMLLSRLLANFTRGESDALRKAMGKKLIEKMNHLKSKFMAGGKTNGYKEE
TLQKIWSDWEKFASYAFNKSHATCYSWVAYQTAFLKANYPSEYMAAVLSRSLSNIVDITK
FMDECKAMGIQVLGPDVNESILKFSVDKNKNIRFGLGAVKGVGEAAVQNIIEERRKNGPY
KDIFDFVERVNLTACNKKNIESLALAGAFDNFGIQREQFFAETGKGEIFLETLVRYGNKF
QTDKSTATNSLFGGDAFIAIAKPEIPKCERWSDLERLNKEKELVGIYLSAHPLDEYRIIL
TYVCNTGMAEINDKENLVGKDLLFGGIVTDFREGMTKKGNPYGIIKIEDFTGSGEIALFG
KDYVDYSKFGKRGMYLLIKARVEDRYNSGRLSLSIGAIQLLQEEKDRLIEKISITVPIHD
LDEPTINELSTLIKNNPGQSLLYFKVVDCEHNVIQNFFSQNIRLNVTRNLVEFLQTNENM
DFKING