Protein Info for HMPREF1078_RS11595 in Parabacteroides merdae CL09T00C40

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 667 PF17391: Urocanase_N" amino acids 78 to 204 (127 residues), 166 bits, see alignment E=5.3e-53 PF01175: Urocanase" amino acids 207 to 430 (224 residues), 255.8 bits, see alignment E=4.8e-80 PF17392: Urocanase_C" amino acids 434 to 630 (197 residues), 268 bits, see alignment E=6.3e-84

Best Hits

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 86% identity to pdi:BDI_3644)

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (667 amino acids)

>HMPREF1078_RS11595 urocanate hydratase (Parabacteroides merdae CL09T00C40)
MEVRLSNQLPVYPSFVPGIRRAPDRGYSLTPAQTETALKNALRYIPEELHEVLAPEFMEE
LMTRGRIYGYRYRPEGDLKAKPVDQYKGQCLEGKAFQVMIDNNLSFDIALYPYELVTYGE
TGQVCQNWMQYRLIKQYLEILTSEQTLVIESGHPLGLFRSKPDAPRVIITNSMMVGLFDN
QKDWHIAAQMGVANYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRKKLGIPQDQDLRGHLF
VSSGLGGMSGAQPKAAVIAGAASIIAEVDSSRIQTRHSQGWVQHVTEDKAEAFRMAQEAM
QAREPISIAYHGNIVDLLEFAEAQAIRIDLLSDQTSCHAVYEGGYCPVGISFAERTELLS
HDMDRFCSLVDQSLHRHFEVIKKLVACGTYFFDYGNSFMKAIYDAGVKEISRNGIDEKDG
FIWPSYVEDIMGPELFDYGYGPFRWVCLSGKHEDLVKTDQAAMDCIDPNRRGQDKDNYNW
IRDAETNRLVVGTEARILYQDAEGRLNIALRFNRMVRDGEVGPIMLGRDHHDVSGTDSPF
RETSNIYDGSNVMADMAVQCFAGNAARGMSLVALHNGGGVGIGKAVNGGFGMVLDGSERV
DEILRSAMLWDVMGGVARRSWARNPNAMSTSAAFNENYGDWYHITLPFIPKEDLIQNSIR
TSLKRKV