Protein Info for HMPREF1078_RS07770 in Parabacteroides merdae CL09T00C40

Annotation: GH92 family glycosyl hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 740 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR01180: putative alpha-1,2-mannosidase" amino acids 6 to 733 (728 residues), 811 bits, see alignment E=4.4e-248 PF17678: Glyco_hydro_92N" amino acids 31 to 259 (229 residues), 250.7 bits, see alignment E=1.8e-78 PF07971: Glyco_hydro_92" amino acids 266 to 730 (465 residues), 623.5 bits, see alignment E=2.7e-191

Best Hits

KEGG orthology group: None (inferred from 92% identity to pdi:BDI_1756)

MetaCyc: 75% identical to alpha-1,6-mannosidase (Bacteroides thetaiotaomicron)
3.2.1.-

Predicted SEED Role

"Alpha-1,2-mannosidase" in subsystem Mannose Metabolism

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (740 amino acids)

>HMPREF1078_RS07770 GH92 family glycosyl hydrolase (Parabacteroides merdae CL09T00C40)
MRHISLLAVSLLALAACTPEKQQEADDYTQYVNPFIGTDFTGNTYPGAQVPFGMVQLSPD
NGLPGWDRISGYFYPDTTIAGFSHTHLSGTGAGDLYDISFMPVTRPYKEAPAPLGVYSTF
SHNDEMASAGYYRVLLKDYNINVELTATERCGIQRYTFPKAEASVFLNLKKAMNWDFTLD
SYIEVVDSMTIRGYRFSQGWSPLQHVYFETRFSKPFMACHMDTTSIVTKDRGRIGTAYIA
RFDFNTEKDEEILVTTGISGVSMEGAGKNLRAEVSKDDFDYYQAQAAKTWNKQLSKIEVK
SSDTDDLVKFYTALYHSMIAPTIYSDVDGSYYGPDQQIHKADGWTNYSTFSLWDTYRASH
PLFTYTEPERANDMIKGFLKFNEQNGALPLWNLYGWETNMMIGYHAVPVIVDAYLKGIGN
FDPEKALEACIATANRDDYRGIGDYKKLGYVPAYGDPKKWENWSLSKTLEYAYDDYCIAT
MAKKMGKKEIADEFYKRAQNYRNVYNPATSFMQPRDEKGNFAANFSPDDYTEDICESNGW
QYFWSVPQDLDGLVGLVGSKERFAEKLDSMFTYVPKSTEDLPIFSTGMIGQYAHGNEPSH
HVIYLYNKVGQPWKTQKYVAEVLHNLYQNAPDGICGNEDCGQMSAWFVFSSMGFYPVDPI
SGKYEIGTPIFPEVKMHLANGKTFAVLAPAVSRENIYVQSVKLNGRPYDKSYITHEQIMN
GDTLEFEMGNRPGPVWYNNM