Protein Info for HMPREF1078_RS05470 in Parabacteroides merdae CL09T00C40

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1018 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 337 to 353 (17 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 386 to 411 (26 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 463 to 486 (24 residues), see Phobius details amino acids 526 to 543 (18 residues), see Phobius details amino acids 845 to 865 (21 residues), see Phobius details amino acids 872 to 892 (21 residues), see Phobius details amino acids 898 to 922 (25 residues), see Phobius details amino acids 944 to 964 (21 residues), see Phobius details amino acids 975 to 1000 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1001 (998 residues), 946.9 bits, see alignment E=1.4e-288 PF03176: MMPL" amino acids 330 to 492 (163 residues), 39.2 bits, see alignment E=4.3e-14 amino acids 792 to 1004 (213 residues), 30.8 bits, see alignment E=1.6e-11

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 86% identity to pdi:BDI_3330)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1018 amino acids)

>HMPREF1078_RS05470 efflux RND transporter permease subunit (Parabacteroides merdae CL09T00C40)
MANISEISIKRPVLSTVMTIILLLFGMIGYKFLGVREFPSVDNPIISVNVTYPGANAEVI
MNQITEPLEQNINGIPGIRSLSSVSSQGSCRITVEFELSVDLETAANDVRDKVSRAQRYL
PRDCDPPTVSKADADATPIMQIGIRSSKRSLMELSEIAELTVKERLQTIPNVSGVDIWGQ
KRYSMRLWLDPIKMAGYGITPLDVKNAVDAENVELPSGSIEGNTIDLSIRTLGLMHTATE
FNDLIIKRDGDNIIRFQDVGRAEVSPEDLRSVMRKNGEPMVIDVIIPQPGANQIEIADEA
YKRIEQLKKDLPEDVTVEMVYDNTRFIRASIAEVEETIYVAFLLVVLIIFLFLRDWRVTL
VPVVVIPVSLVGAFFVMYVSGFSINVLTMLAVVLSVGLVVDDAIVMAENIYVRIEQGMEP
KEAGIDGAKEIFFAVVSTTVTLVSVFLPIVFMEGMTGRLFKEFSIVIAGSVTISSFVALT
FTPMLATKLLRKRENKGWLYTKTEPFFEGMNNIYAKSLNAFLNHKWWSIPIVVILFGSIG
YFWRTIRSELSPLEDRSSISINIRAQEGATFEFIRDFTDQVAAMADTLAPERQALTVRAN
NSNGYITVLLPDIKDRERSQMEIADVLSKNVRGKTEARAFVQQQSTFGGRRAGMPVQYVL
QATSLEKLQEYLPAFMQKVSESPVFQMADVNLKFTKPEARIEINRDKASSLGVSTRTIAQ
TLQYALSGQRMGYFYMNGKQYQILGEINRQQRNTPLDLKSIYVRSDAGEMIQLDNLVTLK
EDVAPPQLYRYNRFVSATVSSGLNKGYTIGDGLDEMDRIASETLDNSFRTALSGESKEFR
ESSSSLMFAMILALFMIYLVLAAQFESFKDPLVVMFTVPLAIAGALIFMSYSDITMNIFS
QIGIIMLIGLVAKNGILIVEFANQRQEAGLSMAEAIRSASTQRLRPILMTSISTILGLVP
LVYASGEGAQGRIAMGIAVVGGMIVSTFLTLFIVPAMYSFISTDRQSKINNQELKIKK