Protein Info for HMPREF1058_RS18605 in Phocaeicola vulgatus CL09T03C04

Annotation: hydroxylamine reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 552 TIGR01703: hydroxylamine reductase" amino acids 5 to 546 (542 residues), 749.2 bits, see alignment E=1.1e-229 PF03063: Prismane" amino acids 5 to 544 (540 residues), 608.2 bits, see alignment E=6.4e-187

Best Hits

Swiss-Prot: 66% identical to HCP_BACFR: Hydroxylamine reductase (hcp) from Bacteroides fragilis (strain YCH46)

KEGG orthology group: K00378, hydroxylamine reductase [EC: 1.7.-.-] (inferred from 99% identity to bvu:BVU_2981)

Predicted SEED Role

"Hydroxylamine reductase (EC 1.7.-.-)" in subsystem Nitrosative stress (EC 1.7.-.-)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.7.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9JAB5 at UniProt or InterPro

Protein Sequence (552 amino acids)

>HMPREF1058_RS18605 hydroxylamine reductase (Phocaeicola vulgatus CL09T03C04)
MENNMFCFQCQETAKGFGCTLKGVCGKNATTARTMDLLLFVVRGISVVADQLRQHSLPVE
KEVDNFIVDALFCTITNANFDDESITKRIDKGLAIRDDLKHQASAKDIPLPEADELNWKG
SRDEYDAKAATVGVLREQNEDLRSLKELIMYGLKGMAAYLEHAMRLGHNDESIHRFMQNT
IAQITTKSLSADELTALALKTGEIGVRTMALLDKANTSRYGNPEITHVNIGTGTRPGILI
SGHDLHDLEELLEQTKDSGVDVYTHGEMLPAHYYPAFKKYTHFAGNYGNAWWKQREEFTS
FNGPILFTTNCIVPPLPNATYKERMFTTNSTGYPGCKHITADEKGHKDYSEIIETAKQCA
APTEIEHGEIVGGFAHNQVLQLADKVVEAVKSGAIRKFIVMAGCDGRMRSRDYYTAFAEM
LPKDTVILTAGCAKYRYNKLGLGEINGIPRVLDAGQCNDSYSLAVIALKLKEVFGLHDIN
ELPIVYNIAWYEQKAVIVLLALLSLGIKEIHLGPTLPAFLSPNVTKVLVENFGVSGIGTV
ESDMRKWGLTNG