Protein Info for HMPREF1058_RS14420 in Phocaeicola vulgatus CL09T03C04

Annotation: TlpA family protein disulfide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 449 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF08534: Redoxin" amino acids 315 to 435 (121 residues), 68.1 bits, see alignment E=1.9e-22 PF00578: AhpC-TSA" amino acids 315 to 427 (113 residues), 57.2 bits, see alignment E=4.2e-19 PF13098: Thioredoxin_2" amino acids 333 to 426 (94 residues), 27.4 bits, see alignment E=9.1e-10 PF13905: Thioredoxin_8" amino acids 335 to 426 (92 residues), 63.6 bits, see alignment E=4.4e-21 PF00085: Thioredoxin" amino acids 336 to 383 (48 residues), 32.6 bits, see alignment 1.7e-11

Best Hits

KEGG orthology group: None (inferred from 99% identity to bvu:BVU_1977)

Predicted SEED Role

"Thiol:disulfide interchange protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9A132 at UniProt or InterPro

Protein Sequence (449 amino acids)

>HMPREF1058_RS14420 TlpA family protein disulfide reductase (Phocaeicola vulgatus CL09T03C04)
MRTLKSIMVLGLALSTFTATEAAKLTFKVTNPNEKVKVRLTFSQSGEQKEVAIDAAGNGN
IEITGFTPQYVTMQYTRGRRTLYLDPNQDLTLSFDSDNMWRNTTFEGAGAAINTYLGSKE
LQSLGMPDMKMQEAALIHKGDSLYAANCQVLEAAKLPADFTTQEKIRLQFYTYYYFSKYA
LYHPHFGKDDNYIPSKAYYEKLEAITPINASLLALKEYKAFLPDAISAFSNKGKTVASSS
TEQSVNYVDATIQDEKVAEFLIDQFVYNFVDNNGLDEADGLIVLFRKHVKDAKSIEKFNA
LCTKWEKLRSGNPSAASFSYPDINGKTVSLADLKGKYIYIDVWATWCGPCRGELPALKEL
EEKYAGKDIHFVSLSCDKNKKAWENMVTKDQLKGIQLHMGTDRTFMDAYLINGIPRFILL
DRDGKIISANMTRPSDPKTAEKFNELLGL