Protein Info for HMPREF1058_RS05605 in Phocaeicola vulgatus CL09T03C04

Annotation: type II toxin-antitoxin system HipA family toxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 363 PF13657: Couple_hipA" amino acids 8 to 114 (107 residues), 58.3 bits, see alignment E=9.7e-20 PF07804: HipA_C" amino acids 159 to 355 (197 residues), 154.7 bits, see alignment E=2.8e-49

Best Hits

KEGG orthology group: K07154, (no description) (inferred from 40% identity to eel:EUBELI_01637)

Predicted SEED Role

"HIPA PROTEIN"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9U2P3 at UniProt or InterPro

Protein Sequence (363 amino acids)

>HMPREF1058_RS05605 type II toxin-antitoxin system HipA family toxin (Phocaeicola vulgatus CL09T03C04)
MNNIKQIEVIYDSRVVGRLALTKEGLCAFEYSAEWLNTGFSISPFELPLRSGVFVARPRP
FEGGFGAFDDCLPDGWGLLILDRYLQQKGINPRTLSLLERLALVGSTGRGALEFRPDKSV
VSKQEYTDFEKLALNAEQILDSEDYTGEGIEEFQYRGGSPGGARPKIFTRFEDKEWLVKF
RAKRDSKRIGVDEYNYSLLAKKCGIEMPETRLFEEKYFGVERFDRTSNGKLHVVSIAGLI
GADYRLPSIDYTHIFQVCATLTHSVAEMWKVYRLMVFNYLIDNKDDHAKNFAFIYRDGDW
HFAPAYDLLPSDGINGFHTTSINDSIEPTKEDLFAVAVKVGLNEKEVIEVFEKMEKYIGA
YFV