Protein Info for HMPREF1058_RS01235 in Phocaeicola vulgatus CL09T03C04

Annotation: phosphoserine phosphatase SerB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 PF13740: ACT_6" amino acids 6 to 80 (75 residues), 89.6 bits, see alignment E=2.9e-29 PF21086: ACT_PSP_2" amino acids 102 to 182 (81 residues), 30.6 bits, see alignment E=8.9e-11 TIGR00338: phosphoserine phosphatase SerB" amino acids 184 to 396 (213 residues), 272 bits, see alignment E=3.7e-85 PF00702: Hydrolase" amino acids 193 to 366 (174 residues), 82.4 bits, see alignment E=1.8e-26 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 194 to 364 (171 residues), 123.7 bits, see alignment E=8e-40 PF12710: HAD" amino acids 196 to 362 (167 residues), 81.6 bits, see alignment E=3.2e-26 PF08282: Hydrolase_3" amino acids 328 to 397 (70 residues), 41.9 bits, see alignment E=3.2e-14

Best Hits

KEGG orthology group: K01079, phosphoserine phosphatase [EC: 3.1.3.3] (inferred from 100% identity to bvu:BVU_3158)

Predicted SEED Role

"Phosphoserine phosphatase (EC 3.1.3.3)" in subsystem Glycine and Serine Utilization or Serine Biosynthesis (EC 3.1.3.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.3.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9TW46 at UniProt or InterPro

Protein Sequence (410 amino acids)

>HMPREF1058_RS01235 phosphoserine phosphatase SerB (Phocaeicola vulgatus CL09T03C04)
MNNNTELILIRITGLDRPGLTASITEILSKYDVTILDIGQADIHSTLSLGILFKSQEKDS
GNIMKELLFKASALGINIRFYPVTVEEYEEWVNMQGKNRYILTLLGRKLTAKQIAAVTGI
LAEQGLNIDAIKRLTGRIPLDERKANVRACIEFSVRGTPRQREEMQQALMKLSSDLEMDF
SFQLDNMYRRMRRLICFDMDSTLIQTECIDELAERAGVGDQVREITERAMRGEIDFIESF
TERVALLKGLDESVMKEIAENLPITEGVERLMFVLKRYGYKIAILSGGFTYFGNYLKDKF
GIDYVYANELEIVNGKLTGRYLGDVVDGKRKAELLKLIAQVERVDIAQTIAVGDGANDLP
MLSEAGLGIAFHAKPKVVANAQQSINTIGLDGVLYFLGFKDSYLEERGKL