Protein Info for H281DRAFT_06248 in Paraburkholderia bryophila 376MFSha3.1

Annotation: protein translocase subunit secA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 936 PF07517: SecA_DEAD" amino acids 6 to 405 (400 residues), 440.1 bits, see alignment E=1.1e-135 TIGR00963: preprotein translocase, SecA subunit" amino acids 28 to 827 (800 residues), 1140.6 bits, see alignment E=0 PF00270: DEAD" amino acids 99 to 216 (118 residues), 26.3 bits, see alignment E=1.7e-09 PF01043: SecA_PP_bind" amino acids 232 to 361 (130 residues), 132.4 bits, see alignment E=3.1e-42 PF21090: P-loop_SecA" amino acids 422 to 625 (204 residues), 315.8 bits, see alignment E=3.5e-98 PF07516: SecA_SW" amino acids 627 to 840 (214 residues), 233.2 bits, see alignment E=8.8e-73 PF02810: SEC-C" amino acids 916 to 934 (19 residues), 40 bits, see alignment (E = 8.7e-14)

Best Hits

Swiss-Prot: 89% identical to SECA_BURCA: Protein translocase subunit SecA (secA) from Burkholderia cenocepacia (strain AU 1054)

KEGG orthology group: K03070, preprotein translocase subunit SecA (inferred from 91% identity to bac:BamMC406_0497)

Predicted SEED Role

"Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1)" (TC 3.A.5.1.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MDS6 at UniProt or InterPro

Protein Sequence (936 amino acids)

>H281DRAFT_06248 protein translocase subunit secA (Paraburkholderia bryophila 376MFSha3.1)
MTTGFLQKIFGSRNQRLVKQYQKTVAAINALEPQIEQLTDDQLRAKTDEFRQRVASGESL
DKLLPEAFAVCREASKRVLKMRHFDVQLIGGMVLHYGKIGEMRTGEGKTLVATLPVYLNA
LSGRGVHVVTVNDYLAQRDAEWMARLYNFLGMSVGINLSQMDHEMKQQAYAADITYGTNN
EFGFDYLRDNMVYEPEARVQRALNFAVVDEVDSILIDEARTPLIISGQAEDHTELYVRMN
ALPPLLERQIGEEKADGTGVEKPGDYTLDEKGRQVFLTESGHEKAERLLAEWGLIGEGES
LYAPQNITLMHHVYAALRAHTLFYKDQHYVVQNGEVIIVDEFTGRLMAGRRWSDGLHQAV
EAKEHVKIQSENQTLASITFQNYFRMYAKLSGMTGTADTEAYEFNEIYGLETVVIPTNRP
PKRIDKQDQIYKTAKERYDAVIRDIRDCYERGQPVLVGTTSIENSELLSHLLKQAGLPHE
VLNAKQHAREAEIVAEAGRPKRITIATNMAGRGTDIVLGGNAEKQASFIELDETIPDDEK
QRRIQKLHDEWQALHDQVKAAGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSL
EDPLLRIFAGDRVRAIMDRLKMPEGEAIEAGIVSRSIESAQRKVEARNFDIRKQLLEYDD
VSNDQRKVIYQQRNELLEANDITETIGAMRHGVIAEIVHQVVPAGSIEEQWDVPELEEVL
RNEWQLDLAIQEMINESNSITSDEILEAVQAAADEAYEAKVELVGRESFSAFERSIMLQT
LDRSWREHLAALDHLRQGIHLRGYAQKNPKQEYKREAFELFAAMLDAVKLEVTRVVMNVQ
IQSPEQLEQAAEQMEEQGGHLENVEFRHAEFAEASSAAPAAAEAATAAMIGDAMSHGSSP
QTASPVGTDNVPKVGRNDPCPCGSGKKYKQCHGKIA