Protein Info for H281DRAFT_05342 in Paraburkholderia bryophila 376MFSha3.1

Annotation: drug resistance transporter, EmrB/QacA subfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 527 transmembrane" amino acids 47 to 70 (24 residues), see Phobius details amino acids 82 to 101 (20 residues), see Phobius details amino acids 113 to 132 (20 residues), see Phobius details amino acids 138 to 162 (25 residues), see Phobius details amino acids 173 to 194 (22 residues), see Phobius details amino acids 201 to 221 (21 residues), see Phobius details amino acids 233 to 251 (19 residues), see Phobius details amino acids 263 to 280 (18 residues), see Phobius details amino acids 301 to 325 (25 residues), see Phobius details amino acids 338 to 359 (22 residues), see Phobius details amino acids 367 to 388 (22 residues), see Phobius details amino acids 394 to 417 (24 residues), see Phobius details amino acids 435 to 456 (22 residues), see Phobius details amino acids 496 to 519 (24 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 48 to 458 (411 residues), 265.1 bits, see alignment E=6.2e-83 PF07690: MFS_1" amino acids 52 to 444 (393 residues), 185.3 bits, see alignment E=2.4e-58 PF06609: TRI12" amino acids 66 to 458 (393 residues), 41.7 bits, see alignment E=8.5e-15 PF00083: Sugar_tr" amino acids 83 to 215 (133 residues), 42.3 bits, see alignment E=7.4e-15

Best Hits

KEGG orthology group: None (inferred from 92% identity to bpy:Bphyt_4890)

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (527 amino acids)

>H281DRAFT_05342 drug resistance transporter, EmrB/QacA subfamily (Paraburkholderia bryophila 376MFSha3.1)
MQQPTQQAVLARPQRLLNDGPQAAVTRHEPASDHSVERAADHPPIRLLFPALLLVMLLAA
LDQTIVSTALPTIVGELGGLNNLSWVVTAYLLSSTIVVPLYGKFGDQFGRKIVLQTAIVL
FLVGSALCGIAQDMTQLIVLRALQGLGGGGLLVVTMAAIADVIPPAQRGRYQGVFGGVFG
LATVVGPLLGGFLVEHLTWRWIFYINLPLGIVSLAVIGAVFKPRLHQVKHTIDYMGAAFL
AGALTCIILFTSQGGTILPWSSPQLWITLGMGLVAIWGFIHEERSAAEPIMPLELFRQRT
FLLSSLIGFIVGVSMFGSVTFLPLYLQVVKGSTPTEAGMQMLPMMGGLFVMSMVTGRLIS
KIGRYRMFPIAGTLLVAIAMMLLARLQIDTPIHVMYLDMGVLGCGLGMVMQVLILAVQNT
VEFKHMGVATSGATLFRSIGGSIGVAAFGAVFSNGLAARLEKLIPPDTELPHALGPAAIR
HLPDALRADYLQAFAGALHTVYLSAACVVLLAFVLAWLLKDHPLREH