Protein Info for H281DRAFT_04712 in Paraburkholderia bryophila 376MFSha3.1

Annotation: DNA mismatch repair protein MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 681 TIGR00585: DNA mismatch repair protein MutL" amino acids 26 to 325 (300 residues), 298 bits, see alignment E=5.6e-93 PF02518: HATPase_c" amino acids 44 to 100 (57 residues), 31.9 bits, see alignment 3.1e-11 PF13589: HATPase_c_3" amino acids 47 to 147 (101 residues), 50.5 bits, see alignment E=4.6e-17 PF01119: DNA_mis_repair" amino acids 228 to 344 (117 residues), 134 bits, see alignment E=4.1e-43 PF08676: MutL_C" amino acids 495 to 637 (143 residues), 157.7 bits, see alignment E=3.3e-50

Best Hits

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 94% identity to bug:BC1001_0464)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5M9G4 at UniProt or InterPro

Protein Sequence (681 amino acids)

>H281DRAFT_04712 DNA mismatch repair protein MutL (Paraburkholderia bryophila 376MFSha3.1)
MSEFSETPVDATAAAATPAVRPLRAILPLPDQLISQIAAGEVVERPASVVKELLENALDA
GARTLRIMLDEGGVKRISITDDGCGIPENELALALMRHATSKIRSLAELEAVATLGFRGE
ALASIASVAQMTITSRTADAPHAVRVDAQTGVLSPAAGTQGTTIEVRELYFNTPARRKFL
KSEQTELGHCLEQIRRAALARPDVAISVLHNGKAVEHWNASEPPARVAKILGETFATAHL
PLDESAGPLAVYGCAGLPTASRGRSDQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYP
SYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHA
AHLQASADGAVSFGTSPGSAGVAGFGASAAGSFVGGLSSNGTPGSTGSGFSASQAGNTWM
RQSRMTQGTLPVAQPLAFYDALFGRKDTSAGTAQGATLFEARDSAAEGPSPYNASASYAP
PAFNPADDQPLGFALGQIHGIYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTIAVQ
PLLIPQTMQADPVEIGTVEEERDTLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARA
VLADLHAYGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNH
GRPTWYQLTLSDLDRLFMRGQ