Protein Info for H281DRAFT_01344 in Paraburkholderia bryophila 376MFSha3.1

Annotation: methylglutaconyl-CoA hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00378: ECH_1
  • amino acids 11 to 261 (251 residues), 186.6 bits, E=5.5e-59
• PF16113: ECH_2
  • amino acids 15 to 243 (229 residues), 106.3 bits, E=2.5e-34

Best Hits

KEGG orthology group: K13766, methylglutaconyl-CoA hydratase [EC: 4.2.1.18] (inferred from 93% identity to bug:BC1001_3993)

MetaCyc: 44% identical to 3-methylglutaconyl-CoA hydratase (Pseudomonas putida)
Methylglutaconyl-CoA hydratase. [EC: 4.2.1.18]

Predicted SEED Role

"Methylglutaconyl-CoA hydratase (EC 4.2.1.18)" in subsystem Benzoate transport and degradation cluster or HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism (EC 4.2.1.18)

MetaCyc Pathways

• L-leucine degradation I (5/6 steps found)
• ferrichrome A biosynthesis (1/5 steps found)

KEGG Metabolic Maps

• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.18

Sequence Analysis Tools

See A0A2Z5MMQ0 at UniProt or InterPro

Protein Sequence (261 amino acids)

>H281DRAFT_01344 methylglutaconyl-CoA hydratase (Paraburkholderia bryophila 376MFSha3.1)
MHYETLNVEFAGHVATVTLNRPDVRNAFNETMIAELTSAFTALDTRDDVRAVVLAANGKA
FCAGADLNWMKKMAAYSDEENRADAMLLANMLSSIYRCSKPVIARVNGDAYAGGMGLISA
CDIVVAVESARFCLSEARLGLIPATIAPYVVRALGEQASRRYFITAEQFDCATALRLGFV
GEAVSAGQLDATVQQIAQTLCANGPQAVRNCKRLVQDMAGRKLNDALIEDTAARIARTRA
GAEGREGVASFLEKRTPAWRD