Protein Info for Ga0059261_1895 in Sphingomonas koreensis DSMZ 15582
Updated annotation (from data): 2-keto-3-deoxyxylonate dehydratase (EC 4.2.1.141)
Rationale: Specifically important in carbon source D-Xylose. 31% identical to HVO_B0027, which is 2-keto-3-deoxyxylonate dehydratase (see PMC2785657). Ga0059261_1895 is also 61% identical to xylX from Caulobacter crescentus, which is also required for xylose utilization (PMC1855722) and is believed to have this activity as well.
Original annotation: Fumarylacetoacetate (FAA) hydrolase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 62% identity to bsb:Bresu_2942)Predicted SEED Role
"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism
MetaCyc Pathways
- D-xylose degradation V (5/5 steps found)
- D-xylose degradation III (4/5 steps found)
- D-arabinose degradation III (3/6 steps found)
- superpathway of pentose and pentitol degradation (12/42 steps found)
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.2.1.141
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1L6J6G9 at UniProt or InterPro
Protein Sequence (376 amino acids)
>Ga0059261_1895 2-keto-3-deoxyxylonate dehydratase (EC 4.2.1.141) (Sphingomonas koreensis DSMZ 15582) VPEAFDVSALPEDAGQATLAGRVMLAEGPVPVIVREGRVHDVSTVAATTADLFDLPDPAS AAGKYLCDVTDLTIGGGAYALLAPIDLQCVKACGVTFAVSALERVIEERARGDAGQAAAI RAELEEKIGGGIRSVVPGSADAAKLKAVLIDAGMWSQYLEVAIGPDAEVFTKAPVLSSVG WGAEIGIRSDSSWNNPEPEVVVIANAAGKVIGATLGNDVNLRDFEGRSALLLGKAKDNNA ACAIGPFVRLFDAQFGIDDVRNAELDLLIEGPEGYRLEGHSSMNQISRDPLELVRQTLSE HQYPDGFALFLGTLFAPVQDRDDPGRGFTHKIGDTVRIRSRKLGTLTNRVTTSKDAAPWT FGIRELYRSIAARTAA