Protein Info for Ga0059261_1374 in Sphingomonas koreensis DSMZ 15582

Annotation: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 272 PF14805: THDPS_N_2" amino acids 4 to 68 (65 residues), 92.1 bits, see alignment E=3.1e-30 TIGR00965: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase" amino acids 5 to 271 (267 residues), 412.9 bits, see alignment E=3.1e-128 PF14602: Hexapep_2" amino acids 175 to 210 (36 residues), 45.3 bits, see alignment 8.6e-16 PF00132: Hexapep" amino acids 176 to 209 (34 residues), 30.2 bits, see alignment 4e-11

Best Hits

Swiss-Prot: 77% identical to DAPD_NOVAD: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD) from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)

KEGG orthology group: K00674, 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase [EC: 2.3.1.117] (inferred from 78% identity to sjp:SJA_C1-01570)

MetaCyc: 66% identical to tetrahydrodipicolinate succinylase (Escherichia coli K-12 substr. MG1655)
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. [EC: 2.3.1.117]

Predicted SEED Role

"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117)" in subsystem Lysine Biosynthesis DAP Pathway (EC 2.3.1.117)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.117

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1L6J962 at UniProt or InterPro

Protein Sequence (272 amino acids)

>Ga0059261_1374 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (Sphingomonas koreensis DSMZ 15582)
MTDLAATIDAAWEDRANISLATTGAVRDAVAEALNLLDSGEARVAEPVADGWQVNQWLKK
AVLLSFRLNDNEVIGTQAGDWGFDKVPLKTAGWDEARFRAAGFRQVPGSVVRHGAFISKN
VVLMPSFVNIGAYVGEGSMVDGWATVGSCAQIGRNVHLSGGVGIGGVLEPLQADPVIIGD
GAFIGARAEVAEGVRVGEGAVLSMGVYLGASTKIVDRATGEVHRGVVPPYSVVVPGTLPG
KDGGPGLYCAVIVKTVDAQTRSKTGINELLRD