Protein Info for Ga0059261_1162 in Sphingomonas koreensis DSMZ 15582

Annotation: copper-(or silver)-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 844 transmembrane" amino acids 178 to 199 (22 residues), see Phobius details amino acids 205 to 230 (26 residues), see Phobius details amino acids 251 to 274 (24 residues), see Phobius details amino acids 281 to 299 (19 residues), see Phobius details amino acids 433 to 455 (23 residues), see Phobius details amino acids 461 to 483 (23 residues), see Phobius details amino acids 777 to 796 (20 residues), see Phobius details amino acids 802 to 823 (22 residues), see Phobius details TIGR00003: copper ion binding protein" amino acids 23 to 83 (61 residues), 52.3 bits, see alignment 1.2e-17 amino acids 89 to 149 (61 residues), 33.8 bits, see alignment 7.4e-12 PF00403: HMA" amino acids 23 to 82 (60 residues), 62.4 bits, see alignment 1.1e-20 amino acids 92 to 150 (59 residues), 56.5 bits, see alignment 7.6e-19 TIGR01511: copper-translocating P-type ATPase" amino acids 231 to 827 (597 residues), 592.7 bits, see alignment E=2.1e-181 TIGR01525: heavy metal translocating P-type ATPase" amino acids 249 to 826 (578 residues), 620.8 bits, see alignment E=6.9e-190 TIGR01494: HAD ATPase, P-type, family IC" amino acids 288 to 794 (507 residues), 283 bits, see alignment E=9.1e-88 PF00122: E1-E2_ATPase" amino acids 317 to 497 (181 residues), 194.6 bits, see alignment E=2.8e-61 PF00702: Hydrolase" amino acids 515 to 731 (217 residues), 125.8 bits, see alignment E=7.5e-40 PF12710: HAD" amino acids 651 to 727 (77 residues), 27.1 bits, see alignment E=1.3e-09 PF08282: Hydrolase_3" amino acids 704 to 763 (60 residues), 23.5 bits, see alignment 1.1e-08

Best Hits

Swiss-Prot: 69% identical to ATCU1_RHIME: Copper-transporting ATPase 1 (actP1) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 74% identity to spe:Spro_2413)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8WAF1 at UniProt or InterPro

Protein Sequence (844 amino acids)

>Ga0059261_1162 copper-(or silver)-translocating P-type ATPase (Sphingomonas koreensis DSMZ 15582)
MSNVMELNRKSVAPASGTAPMSVAVAGMTCASCVGHIEKAVARLPGVVAVSVNLATERAD
VTFAGAPDPQAVIQAIEHAGYQVPEIETELGVEGMTCASCVGHVEKALAGVPGVTAASVN
LATERASIRYRSGIATLGDLEAAVRRAGYTPRRLETDRTAPDREAAARDAELRGLRGSLV
LAAALALPVFVLEMGSHLIPGVHDWVMATIGMQASWLIQFVLTTLVLFGPGLRFFRKGVP
AILRGTPDMNSLVALGTSAAWGYSLVATFAPGVLPAGTANVYYEAAAVIVALILLGRYLE
ARAKGRTSEAIKRLAGLQAKTARVVRDGAVLDVALADVVAGDAVEVRPGERVPVDGDVVE
GSSYVDESMITGEPVPVAKAAGAAVVGGTINTTGAFTFRATKVGADTVLAQIIRMVEQAQ
GSKLPIQAMVDKVTAWFVPVVMGVAALTFAIWLVFGPDPALTFALVNAVAVLIIACPCAM
GLATPTSIMVGTGRAAELGVLFRKGEALQTLRDVSVVALDKTGTLTKGRPELTDLEPAEG
FERDTALALVAAVEARSEHPIAGAIVAAARARGLAVPPAEAFEATPGYGVSAQVGGRAVQ
VGADRFMAKLGHDVSAFAGKAAELGALGRTPLYAAIDGSLAAIIAVADPIRETTPEAIRA
LHDLGLKVAMITGDNQATADAVARTLGIDEVIGEVLPGGKVAALHRLRAADRKIAFVGDG
INDAPALASADVGLAIGTGTDVAIESADVVLMSGDLRGVVNAIALSKATIRNIRENLFWA
FGYNVALIPVAAGALYPLNGALLSPIFAAGAMALSSIFVLTNALRLKAFRPAIAASRHDQ
GEAR