Protein Info for Ga0059261_0354 in Sphingomonas koreensis DSMZ 15582

Annotation: 6-phosphogluconate dehydratase (EC 4.2.1.12)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 608 TIGR01196: phosphogluconate dehydratase" amino acids 7 to 602 (596 residues), 895.9 bits, see alignment E=5.5e-274 PF00920: ILVD_EDD" amino acids 69 to 598 (530 residues), 513.7 bits, see alignment E=2.8e-158

Best Hits

Swiss-Prot: 63% identical to EDD_ZYMMO: Phosphogluconate dehydratase (edd) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

KEGG orthology group: K01690, phosphogluconate dehydratase [EC: 4.2.1.12] (inferred from 71% identity to swi:Swit_1624)

MetaCyc: 56% identical to phosphogluconate dehydratase (Escherichia coli K-12 substr. MG1655)
Phosphogluconate dehydratase. [EC: 4.2.1.12]

Predicted SEED Role

"Phosphogluconate dehydratase (EC 4.2.1.12)" in subsystem Entner-Doudoroff Pathway (EC 4.2.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8W872 at UniProt or InterPro

Protein Sequence (608 amino acids)

>Ga0059261_0354 6-phosphogluconate dehydratase (EC 4.2.1.12) (Sphingomonas koreensis DSMZ 15582)
VTNLLPEIAAVTDRIIERSKKRRAAYNALMTAQREAGSSSRGRLGCANLAHAYAGTDEQR
DVMKPANRMNIGIVTAYNDMLSAHAPYYRYPEQMKIWALEAGATAQVAGGVPAMCDGVTQ
GYAGMELSLFSRDTIAMSTAVALSHNTFEGAALLGICDKIVPGLLMGALRFGHLPMVLIP
GGAMPTGIANKEKARVRELYAEGKASREELLDSEIAAYHGKGTCTFYGTANSNQMMVEAM
GLHMPGAAFIHPGTKLRQALTRAAVQRLPEIGWDSNDYRPIGEIVDERAIVNAAVVLLAT
GGSTNHLIHLPAIARCAGVLIDWDDFDRLSRVVPLLARVYPNGSADVNGFEDAGGPTFVI
RELIKGGVLHGDTLTVAGDSLADYVRRPVLEDDTLVWKDHGAKSGDDSILRTIDAPFSEE
GGFRILSGNLGRACIKVSAVERDRWTIEAPCRVFATQQEVQDAFKAGELDRDVVVVVRFQ
GPRANGMPELHKLTPPLGVLQNKGFRVALVTDGRMSGASGKVPAAIHLSPEAIGGGPIGK
LRDGDVVRLCAEEGILQALVEPAEWEARELAAAPPPDLGTGRELFAMMRAGASEAEAGGS
AMLAAAEL