Protein Info for Psest_1012 in Pseudomonas stutzeri RCH2

Annotation: Signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 948 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 199 to 218 (20 residues), see Phobius details amino acids 230 to 253 (24 residues), see Phobius details amino acids 262 to 283 (22 residues), see Phobius details amino acids 290 to 311 (22 residues), see Phobius details amino acids 317 to 338 (22 residues), see Phobius details amino acids 349 to 371 (23 residues), see Phobius details amino acids 377 to 399 (23 residues), see Phobius details PF07696: 7TMR-DISMED2" amino acids 59 to 184 (126 residues), 83.3 bits, see alignment E=3.9e-27 PF07695: 7TMR-DISM_7TM" amino acids 200 to 401 (202 residues), 69.1 bits, see alignment E=1.3e-22 PF00512: HisKA" amino acids 426 to 490 (65 residues), 72.4 bits, see alignment 6.2e-24 PF02518: HATPase_c" amino acids 537 to 651 (115 residues), 53.8 bits, see alignment E=6.4e-18 PF00072: Response_reg" amino acids 672 to 787 (116 residues), 69.6 bits, see alignment E=6.1e-23 amino acids 821 to 935 (115 residues), 83.2 bits, see alignment E=3.8e-27

Best Hits

KEGG orthology group: None (inferred from 90% identity to psa:PST_3281)

Predicted SEED Role

"Sensor histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GJL1 at UniProt or InterPro

Protein Sequence (948 amino acids)

>Psest_1012 Signal transduction histidine kinase (Pseudomonas stutzeri RCH2)
MAIIRRHTHERTSLVGRLRIAIAVIFGLLLINLIPLSAQAAIAQPSPSTVLVEADSVPQN
WRILIDQSGGLTLDEVLSQRALFQRLDKLSYSAPASNRAVWLQVSLPSLTKPKWLWLFAP
RVQYLDFYLLRDGQLEQHTATGELRPLSARPLPNRAYLFSLPNDGQPREAYIRLQSSHPV
MTWFKTIDDSGLVSQTKPAYLFGALFGALALLMVYNLLRFAYTLSYTHIWLSLLHGALLV
CAVANLGVLAVWLPGLTYSQPLIADLAALLASTALLGYTLGFFHHRGRTWITWLLGLEFN
LILALAGSILLGQWPWYSWLIYSMGLVASFSVLFVALYHWRQGYQPARLVVAGLTLFNSG
MVFFMPMLLGFDQLDPGWLTGGLFSLATLGGLLLSFALLERQRQLQSDSRTQYTAEAVTS
AELKTKADFLSKISHELRTPMNGVLGMSELLLGTSLSAKQRDYVQTIHSSGNELLNLINE
ILDISKLESGQIELDDVQFDFNALIEDCLSIFRAKAEQQKVELISFIQPQLPQVVAGDPT
RLRQTLLNLLENAFKQTDEGEVLLIAAVDGPQDNPRLRITVQDSGRPLEPYERDALLNAA
VDSHDFLASTRHGGRLGLIIARQLVQLMDGDFGIQTGTTQGNTLWISLPLASEGLAQNNA
DLDGPLQGTRLLIVDDNDTCRKVLVQQCSAWGLEVSAVASGKEALALLRTKAHLREYFDV
VLLDQDMPGMTGMQLASKIKEDSSLNHDILLIMLTGMGSAPSKIIARNAGIKRILAKPVA
GYTLKTTLADELAQRLQSSQLRPALASPPLAPLEVPSDFRILVAEDNNISTKVIRGMLNK
LNLQPDTACNGEEALEAIKTQPYDLVLMDCEMPVLDGFQATQQLREWEARNGRSRTPVVA
LTAHILSEHRERAREAGMDGHMAKPVELSHLRELIDHWVRVKQAESVD