Protein Info for HP15_96 in Marinobacter adhaerens HP15

Annotation: lipoprotein signal peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 171 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 68 to 88 (21 residues), see Phobius details amino acids 97 to 116 (20 residues), see Phobius details amino acids 136 to 157 (22 residues), see Phobius details TIGR00077: signal peptidase II" amino acids 13 to 159 (147 residues), 146.1 bits, see alignment E=4.4e-47 PF01252: Peptidase_A8" amino acids 18 to 153 (136 residues), 147.8 bits, see alignment E=1.2e-47

Best Hits

Swiss-Prot: 63% identical to LSPA_SERMA: Lipoprotein signal peptidase (lspA) from Serratia marcescens

KEGG orthology group: K03101, signal peptidase II [EC: 3.4.23.36] (inferred from 88% identity to maq:Maqu_3274)

MetaCyc: 41% identical to lipoprotein signal peptidase (Escherichia coli K-12 substr. MG1655)
Signal peptidase II. [EC: 3.4.23.36]

Predicted SEED Role

"Lipoprotein signal peptidase (EC 3.4.23.36)" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes or Signal peptidase (EC 3.4.23.36)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.4.23.36

Use Curated BLAST to search for 3.4.23.36

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJ41 at UniProt or InterPro

Protein Sequence (171 amino acids)

>HP15_96 lipoprotein signal peptidase (Marinobacter adhaerens HP15)
MSGDRSRFFTLNFLGFSTLIALADQAIKWLVQQSMAYGQSVEITSFFNWVHVWNKGAAFS
LFADGGGWQRYFFIAIAVVVSAVLVKLIRDSHQRTEALAYAMVLGGALGNVIDRVFRGHV
VDYLDFHWQSWHWPAFNLADVFIVLGVIMILVTGFTAEKGVGNNTKNRQNG