Protein Info for PGA1_c09150 in Phaeobacter inhibens DSM 17395

Annotation: adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 TIGR00508: adenosylmethionine-8-amino-7-oxononanoate transaminase" amino acids 16 to 427 (412 residues), 559.5 bits, see alignment E=1.9e-172 PF00202: Aminotran_3" amino acids 28 to 424 (397 residues), 391.4 bits, see alignment E=2e-121

Best Hits

Swiss-Prot: 52% identical to BIOA_HAEIN: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K00833, adenosylmethionine-8-amino-7-oxononanoate aminotransferase [EC: 2.6.1.62] (inferred from 57% identity to pde:Pden_2919)

Predicted SEED Role

"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.62

Use Curated BLAST to search for 2.6.1.62

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EKA7 at UniProt or InterPro

Protein Sequence (432 amino acids)

>PGA1_c09150 adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA (Phaeobacter inhibens DSM 17395)
MSAADLTQLEFDQQYLWHPYTNVAKPGPTFVVKESEGVHITLDDGTRLIDAMSSWWCMMH
GHRNPAITSAIHAQLDTLPHVMFGGLTHDPAIDLGRKLLEITPESLTRIFYCDSGSVSVE
VAMKMAVQYQHAIGQPERKEFATIRSGYHGDTWKAMSVCDPDTGMHHLFQGALSVQHFVS
RPPVRIHEDWSDDPAQNGLGELRAVLEAGQDKIAAFILEPVVQGTGGMYFYHPEYLNQAR
ALCDELGILLIFDEIATGFGRTGALFATNFCDAEPDIICLGKGLTGGHISFACTMTNDRV
AEGVGGGNPGIFMHGPTYMANPLACAAAKASLDLLTGQDWRGTVSGIAEQMQSELATARE
LPNVADVRVLGAIGVIEMKHAVSADEAHARAHDMGVFLRPFGKNIYTMPPFITTPDQLSQ
ITAGMLRLAREL